Evaluating Axon Conduction Characteristics of Cultured Sensory Neurons Toward Soft Robot Control

Kenta Shimba; Kiyoshi Kotani; Yasuhiko Jimbo

doi:10.20965/jrm.2022.p0263

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JRM Vol.34 No.2 pp. 263-265

doi: 10.20965/jrm.2022.p0263

(2022)

Letter:

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Evaluating Axon Conduction Characteristics of Cultured Sensory Neurons Toward Soft Robot Control

Kenta Shimba^*, Kiyoshi Kotani^**, and Yasuhiko Jimbo^*

^*School of Engineering, The University of Tokyo
7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

^**Research Center for Advanced Science and Technology, The University of Tokyo
4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan

Received:

September 20, 2021

Accepted:

October 11, 2021

Published:

April 20, 2022

Keywords:

axon, microelectrode array, conduction modulation, soft robot control

Abstract

Information processing in axons has attracted attention for potential application in the control of soft robots. In this letter, we present the evaluation of axon conduction properties in cultured sensory neurons. Distal axons showed latency oscillations in response to high-frequency stimulation, thereby suggesting the suitability of our method for evaluating the information processing function of axons. Understanding axon information processing has a potential to contribute to the development of an advanced control method for soft robots.

Axonal response to electrical stimuli

Cite this article as:

K. Shimba, K. Kotani, and Y. Jimbo, “Evaluating Axon Conduction Characteristics of Cultured Sensory Neurons Toward Soft Robot Control,” J. Robot. Mechatron., Vol.34 No.2, pp. 263-265, 2022.

Data files:

References

[1] T. Sasaki, N. Matsuki, and Y. Ikegaya, “Action-potential modulation during axonal conduction,” Science, Vol.331, Issue 6017, pp. 599-601, 2011.
[2] D. J. Bakkum, U. Frey, M. Radivojevic, T. L. Russell, J. Muller, M. Fiscella, H. Takahashi, and A. Hierlemann, “Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites,” Nat. Commun., Vol.4, 2181, 2013.
[3] N. Endo, Y. Kizaki, and N. Kamamichi, “Flexible Pneumatic Bending Actuator for a Robotic Tongue,” J. Robot. Mechatron., Vol.32, No.5, pp. 894-902, 2020.
[4] K. Shimba, K. Sakai, T. Isomura, K. Kotani, and Y. Jimbo, “Axonal conduction slowing induced by spontaneous bursting activity in cortical neurons cultured in a microtunnel device,” Integr. Biol., Vol.7, pp. 64-72, 2015.
[5] M. K. Lewandowska, D. J. Bakkum, S. B. Rompani, and A. Hierlemann, “Recording Large Extracellular Spikes in Microchannels along Many Axonal Sites from Individual Neurons,” PloS one, Vol.10, e0118514, 2015.
[6] K. Sakai, K. Shimba, K. Kotani, and Y. Jimbo, “A co-culture microtunnel technique demonstrating a significant contribution of unmyelinated Schwann cells to the acceleration of axonal conduction in Schwann cell-regulated peripheral nerve development,” Integr. Biol., Vol.9, pp. 678-686, 2017.
[7] M. Radivojevic, F. Franke, M. Altermatt, J. Muller, A. Hierlemann, and D. J. Bakkum, “Tracking individual action potentials throughout mammalian axonal arbors,” eLife, Vol.6, e30198, 2017.

This article is published under a Creative Commons Attribution-NoDerivatives 4.0 Internationa License.

[1] [1] T. Sasaki, N. Matsuki, and Y. Ikegaya, “Action-potential modulation during axonal conduction,” Science, Vol.331, Issue 6017, pp. 599-601, 2011.

[2] [2] D. J. Bakkum, U. Frey, M. Radivojevic, T. L. Russell, J. Muller, M. Fiscella, H. Takahashi, and A. Hierlemann, “Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites,” Nat. Commun., Vol.4, 2181, 2013.

[3] [3] N. Endo, Y. Kizaki, and N. Kamamichi, “Flexible Pneumatic Bending Actuator for a Robotic Tongue,” J. Robot. Mechatron., Vol.32, No.5, pp. 894-902, 2020.

[4] [4] K. Shimba, K. Sakai, T. Isomura, K. Kotani, and Y. Jimbo, “Axonal conduction slowing induced by spontaneous bursting activity in cortical neurons cultured in a microtunnel device,” Integr. Biol., Vol.7, pp. 64-72, 2015.

[5] [5] M. K. Lewandowska, D. J. Bakkum, S. B. Rompani, and A. Hierlemann, “Recording Large Extracellular Spikes in Microchannels along Many Axonal Sites from Individual Neurons,” PloS one, Vol.10, e0118514, 2015.

[6] [6] K. Sakai, K. Shimba, K. Kotani, and Y. Jimbo, “A co-culture microtunnel technique demonstrating a significant contribution of unmyelinated Schwann cells to the acceleration of axonal conduction in Schwann cell-regulated peripheral nerve development,” Integr. Biol., Vol.9, pp. 678-686, 2017.

[7] [7] M. Radivojevic, F. Franke, M. Altermatt, J. Muller, A. Hierlemann, and D. J. Bakkum, “Tracking individual action potentials throughout mammalian axonal arbors,” eLife, Vol.6, e30198, 2017.

Evaluating Axon Conduction Characteristics of Cultured Sensory Neurons Toward Soft Robot Control

Kenta Shimba*, Kiyoshi Kotani**, and Yasuhiko Jimbo*

Kenta Shimba^*, Kiyoshi Kotani^**, and Yasuhiko Jimbo^*