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JRM Vol.22 No.5 pp. 623-630
doi: 10.20965/jrm.2010.p0623
(2010)

Paper:

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2DOF Magnetically Driven Microtool for Soft Peeling of Zona Pellucida

Yoko Yamanishi*, Tomohiro Kawahara**, Tomohiro Iyanagi***,
Masaya Hagiwara**, Takehito Mizunuma***, Naoki Inomata**,
Shogo Kudo**, and Fumihito Arai***

*JST PRESTO, Department of Mechanical Science & Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan

**Nagoya University, Japan

***Tohoku University, 6-6-01 Aramaki-Aoba, Aoba-ku, Sendai 980-8579, Japan

Received:
February 20, 2010
Accepted:
June 10, 2010
Published:
October 20, 2010
Creative Commons License
Keywords:
cell manipulation, magnetically driven microtool, biochip, photolithography, actuator
Abstract
We automated removal of the swine oocyte zona pellucida using a 2DOF magnetically driven microtool (MMT) on a microfluidic chip. Multiple oocytes can be manipulated simultaneously highly stably, providing strong advantages over conventional manual manipulation using pipetting. We propose automating this process by activating a soft polymer microtool on a disposable microfluidic chip to stably mass-produce peeled oocytes - a breakthrough in high throughput and effective oocyte manipulation in cloning and fertility treatment.
Cite this article as:
Y. Yamanishi, T. Kawahara, T. Iyanagi, M. Hagiwara, T. Mizunuma, N. Inomata, S. Kudo, and F. Arai, “2DOF Magnetically Driven Microtool for Soft Peeling of Zona Pellucida,” J. Robot. Mechatron., Vol.22 No.5, pp. 623-630, 2010.
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References
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