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JRM Vol.22 No.5 pp. 623-630
doi: 10.20965/jrm.2010.p0623
(2010)

Paper:

2DOF Magnetically Driven Microtool for Soft Peeling of Zona Pellucida

Yoko Yamanishi*, Tomohiro Kawahara**, Tomohiro Iyanagi***,
Masaya Hagiwara**, Takehito Mizunuma***, Naoki Inomata**,
Shogo Kudo**, and Fumihito Arai***

*JST PRESTO, Department of Mechanical Science & Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan

**Nagoya University, Japan

***Tohoku University, 6-6-01 Aramaki-Aoba, Aoba-ku, Sendai 980-8579, Japan

Received:
February 20, 2010
Accepted:
June 10, 2010
Published:
October 20, 2010
Keywords:
cell manipulation, magnetically driven microtool, biochip, photolithography, actuator
Abstract

We automated removal of the swine oocyte zona pellucida using a 2DOF magnetically driven microtool (MMT) on a microfluidic chip. Multiple oocytes can be manipulated simultaneously highly stably, providing strong advantages over conventional manual manipulation using pipetting. We propose automating this process by activating a soft polymer microtool on a disposable microfluidic chip to stably mass-produce peeled oocytes – a breakthrough in high throughput and effective oocyte manipulation in cloning and fertility treatment.

Cite this article as:
Yoko Yamanishi, Tomohiro Kawahara, Tomohiro Iyanagi,
Masaya Hagiwara, Takehito Mizunuma, Naoki Inomata,
Shogo Kudo, and Fumihito Arai, “2DOF Magnetically Driven Microtool for Soft Peeling of Zona Pellucida,” J. Robot. Mechatron., Vol.22, No.5, pp. 623-630, 2010.
Data files:
References
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