On-Chip Droplet Dispensing by a Magnetically Driven Microtool
Yoko Yamanishi, Yuki Kihara, Shinya Sakuma, and Fumihito Arai
Department of Bioengineering and Robotics, Tohoku University, 6-6-01 Aramaki-Aza-Aoba, Aoba-ku, Sendai, Miyagi 980-8579, Japan
We have investigated an active size controlled droplet generation system by using magnetically driven microtool (MMT). With a lateral motion of the MMT in microchannels, the continuous phase can be pinched off by the movement of MMT to obtain size-controlled droplets actively. With this method particle-enclosed droplet can be produced on demand to fit the size of each enclosed particle, and which is difficult to carry out by fluid dynamic force. For the current study, the system has been evaluated in terms of the frequency of MMT actuation and the size of droplets produced and which contribute to the effective transportation of cells in microchannel.
-  M. Seo, C. Paquet, Z. Nie, S. Xu, and E. Kumacheva, “Microfluidic consecutive flow-focusing droplet generators,” Lab on a chip, Vol.3, pp. 986-992, 2007.
-  S.-Y. Teh, R. Lin, L.-H. Hung, and A. P. Lee, “Droplet microfluidics,”Lab on a chip, Vol.8, pp. 198-220, 2008.
-  T. Nisisako, T. Torii, and T. Higuchi, “Novel microreactors for functional polymer beads,”Chemical Engineering Journal, Vol.101, pp. 23-29, 2004.
-  Q. Lu, Z. Weng, G. Shan, G. Lai, and Z. Pan, “Effect of Acrylonitrile Water Solubility on the Suspension Copolymerization of Acrylonitrile and Styrene,”Journal of Applied Polymer Science, Vol.101, pp. 4270-4274, 2006.
-  P. Garstecki, H. A. Stone, and G. M. Whiteside, “Mechanism for Flow-Rate Controlled Breakup in Confined Geometries: A Route to Monodisperse Emulsions,”Physical Review Letter, Vol.94, No.164501, 2005.
-  D. R. Link, S. L. Anna, D. A. Weitz, and H. A. Stone, “Geometrically Meditated Breakup of Drops in Microfluidic Devices,”Physical Review Letter, Vol.92, No.054503, 2004.
-  I. Kobayashi, K. Uemura, and M. Nakajima, “Controlled Generation of Mono-disperse Discoid Droplets Using Microchannel Arrays,”Langmuir, 22, 10893-10897, 2006.
-  C.-H. Lee, S.-K. Hsiung, and G.-B. Lee, “An Active Flow Focusing Microfluidic Chip Utilizing Controllable Moving Walls for the Formation of Microdroplets in Liquid,”Proc. of the 2nd IEEE Int. Conf. on Nano/Micro Engineering and Molecular systems, pp. 167-171, 2007.
-  C.-W. Lai, Y.-H. Lin, and C.-B. Lee, “A microfluidic chip for formation and collection of emulsion droplets utilizing active pneumatic micro-choppers and micro-switches,”Biomedical Microdevices, 10, pp. 749-756, 2008.
-  Y. C. Tan and A. P. Lee, “Microfluidic separation of satellite droplets as the basis of a monodispersed micron and submicron emulsification system,”Lab on a Chip, 5, No.10, pp. 1178-1183, 2005.
-  Y. Yamanishi, Y. C. Lin, and F. Arai, “Magnetically Modified PDMS Devices for Active Microfluidic Control,”μ-TAS2007, pp. 883-885, 2007.
-  Y. Yamanishi, S. Sakuma, and F. Arai, “Magnetically Modified Soft Micro Actuator for Oocyte Manipulation,”IEEE Int. Symposium on Micromechatronics and Human Science (MHS), pp. 442-447, 2007.
-  Y. Yamanishi, Y. C. Lin, and F. Arai, “Magnetically modified PDMD microtools for micro particle manipulation,”Proc. of the 2007 IEEE/RSJ Int. Conf. on Intelligent Robotics and Systems, pp. 753-758, 2007.
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