JRM Vol.21 No.2 pp. 209-215
doi: 10.20965/jrm.2009.p0209


Magnetically Driven Microtools Actuated by a Focused Magnetic Field for Separating of Microparticles

Shinya Sakuma, Yoko Yamanishi, and Fumihito Arai

Department of Bioengineering and Robotics, Tohoku University, 6-6-01 Aramaki-Aza-Aoba, Aoba-ku, Sendai, Miyagi 980-8579, Japan

October 20, 2008
January 17, 2009
April 20, 2009
magnetically driven microtool, microactuator, μTAS, sorter

We succeeded in reducing magnetic interaction region with a focused magnetic field on-chip. Novelty of this paper is summarized as follows. (1) We used neodymium powder as the main component of magnetically driven microtools (MMT). The density of magnetic flux was improved by about 100 times after magnetization. (2) We fabricated a couple of pin mounted under a microfluidic chip. The density of magnetic flux was improved by about 1.8 times. As a result, the density of magnetic flux had a single peak using the pin, unlike in a setup without pins. It was confirmed that the size of the magnetic interaction region for the current setting was one twentieth that of the previous setting.

Cite this article as:
Shinya Sakuma, Yoko Yamanishi, and Fumihito Arai, “Magnetically Driven Microtools Actuated by a Focused Magnetic Field for Separating of Microparticles,” J. Robot. Mechatron., Vol.21, No.2, pp. 209-215, 2009.
Data files:
  1. [1] J. M. Song, G. D. Griffin, and T. Vo-Dinh, “Application of an integrated microchip system with capillary array electrophoresis to optimization of enzymatic reactions,” Analytica Chimica Acta, Vol.487, pp. 75-82, 2003.
  2. [2] G. V. Kaigala, V. N. Hoang, A. Stickel, J. Lauzon, D. Manage, L. M. Pilarskib, and C. J. Backhouse, “An inexpensive and portable microchip-based platform for integrated RT-PCR and capillary electrophoresis,” Analyst, Vol.133, pp. 331-338, 2008.
  3. [3] J. C. Giddings, “Field-Flow Fractionation: Analysis of Macromolecular, Colloidal, and Particulate Materials,” Science, Vol.260, pp. 1456-1465, 1993.
  4. [4] J. C. Giddings, “Cell Separation by Dielectrophoretic Field Flow Fractionation,” Anal. Chem., Vol.72, pp. 832-839, 2000.
  5. [5] C. M. Miller, E. D. Sudol, C. A. Silebi, and El-Aasser, “Capillary Hydrodynamic Fraction (CHDF) as a Tool for Monitoring the Evolution of the Size Distribution during Miniemulsion Polymerization,” Journal of Colloid and Interface Science, Vol.172, pp. 249-256, 1995.
  6. [6] Y. Jiang, A. Kummerow, and M. Hansen, “Preparative Particle Separation by Continuous SPLITT Fraction,” Journal of Microcolumn, Vol.9, pp. 261-273, 1997.
  7. [7] M. R. Melamed, T. Lindmo, and M. L. Mendelsohn, “Flow Cytometry and Sorting,” second edition, Wiley-Liss, New York, USA, 1991.
  8. [8] G. Fuhr, R. Hagedorn, T. Muller, B. Wagner, and W. Benecke, “Linear motion of dielectric particles and living cells in microfabricated structures induced by traveling electric fields,” Proc. of IEEE Micro Electro Mechanical systems, pp. 259-264, 1991.
  9. [9] T. Schnelle, T. Muller, G. Gradl, S. G. Shirley, and G. Fuhr, “Paired Microelectrode System: Dielectrophoretic Particle Sorting and Force Calibration,” Journal of Electrostatics, Vol.47, pp. 121-132, 1999.
  10. [10] H. A. Pohl, “Dielectrophoresis, 1,” Cambridge University Press, Cambridge, 1978.
  11. [11] F. Arai, A. Ichikawa, M. Ogawa, T. Fukuda, K. Horio, and K. Itoigawa, “High-speed separation systems of randomly suspended single living cells by laser trap and dielectrophoresis,” Electrophoresis, Vol.22, pp. 283-288, 2001.
  12. [12] Y. Shirasaki, H. Makazu, K. Tashiro, S. Ikeda, T. Sekiguchi, S. Shoji, S. Tsukita, and T. Funatsu, “A Novel Biomolecule Sorter Using Thermosensitive Hydrogel in Micro Flow System,” Proc. of the Micro Total Analysis Systems 2002 (μ-TAS2002), pp. 925-927, 2002.
  13. [13] A. Ashkin and J. M. Dziedzic, “Optical trapping and manipulation of viruses and bacteria,” Science, Vol.235, pp. 1517, 1987.
  14. [14] O. Cugat, J. Delamare, and G. Reyne, “Magnetic Micro-Actuators and Systems (MAGMAS),” IEEE Transactions on magnetics, Vol.39, No.5, pp. 3607-3612, 2003.
  15. [15] N. Pamme, “Magnetism and microfluidics,” Lab on a Chip, Vol.6, pp. 24-38, 2006.
  16. [16] F. H. C. Crick and A. F. W. Hughes, “The physical properties of cytoplasm - A study by means of the magnetic particle method,” Experimental Cell Research 1, pp. 37-80, 1949.
  17. [17] F. H. C. Crick and A. F. W. Hughes, “The physical properties of cytoplasm-A study by means of the magnetic particle method,” Experimental Cell Research 2, pp. 505-533, 1950.
  18. [18] J. J. Abbott, Z. Nagy, F. Beyeler, and B. J. Nelson, “Robotics in the Small,” IEEE Robotics & Automation Magazine, pp. 92-103, June 2007.
  19. [19] G. A. Mensing, T. M. Pearce, M. D. Graham, and D. J. Beebe, “An Externally driven magnetic microstirrer,” Phil. Trans. R. Soc. Lond. A 362, pp. 1059-1068, 2004.
  20. [20] K. S. Kashan, K. Shaikh, S. E. Goluch, Z. Fan, and C. Liu, “Micro magnetic stir-bar mixer integrated with parylene microfluidic channels,” Lab on a Chip, Vol.4, pp. 608-613, 2004.
  21. [21] M. Barbic, J. J. Mock, A. P. Gray, and S. Schults, “Electromagnetic micromotor for microfluidics applications,” Applied Physics Letters, Vol.79(9), pp. 1399-1401, 2001.
  22. [22] W. C. William, M. J. O'Brien, E. Rabinovich, and G. P. Lopez, “Rapid prototyping of active microfluidic components based on magnetically modified elastomeric materials,” Journal of Vacuum Science and Technology, B19(2), pp. 596-599, 2001.
  23. [23] H. Maruyama, F. Arai, and T. Fukuda, “On-Chip microparticle handling using magnetically driven microdevice,” μ-TAS2005, pp. 1422-1424, 2005.
  24. [24] Y. C. Lin, Y. Yamanishi, and F. Arai, “On-chip Temperature Sensing and Control for Cell Immobilisation,” 2nd IEEE Int. Conf. on NEMS, pp. 659-663, Bankok, Thailand, January 2007.
  25. [25] Y. Yamanishi, Y. C. Lin, and F. Arai, “Magnetically Modified PDMD Microtools for Micro Particle Manipulation,” Proc. of the 2007 IEEE/RSJ Int. Conf. on Intelligent Robotics and Systems, pp. 753-758, 2007.
  26. [26] Y. Yamanishi, Y. C. Lin, and F. Arai, “Magnetically Modified PDMS Devices for Active Microfluidic Control,” μ-TAS2007, pp. 883-885, 2007.
  27. [27] Y. Yamanishi, S. Sakuma, and F. Arai, “Magnetically Modified Soft Micro Actuator for Oocyte Manipulation,” IEEE Int. Symposium on Micromechatronics and Human Science (MHS), pp. 442-447, 2007.
  28. [28] Y. Yamanishi, S. Sakuma, K. Onda, and F. Arai, “Biocompatible Polymeric Magnetically Driven Microtool for Particle Sorting,” Journal of Micro - Nano Mechatronics, Vol.4, No.1, pp. 49-57, 2008.
  29. [29] C. Liu and Y. W. Yi, “Micromachined magnetic actuators using electroplated permalloy,” IEEE Trans. on Magnetics, Vol.35(3), pp. 1975-1985, 1999.
  30. [30] H. Rostaing, J. Delamare, O. Cugat, and C. Locatelli, “Magnetic levitation actuator,” US Patent 7142078, Nov. 28, 2006.
  31. [31] M. Dauge, M. Gauthier, and E. Piat, “Modelling of a planar magnetic micropusher for biological cell manipulations,” Sensors and Actuators A, Vol.138, pp. 239-247, 2007.
  32. [32] G. Friedman and B. Yellen, “Magnetic separation, manipulation and assembly of solid phase in fluids,” Current Opinion in Colloid & Interface Science, Vol.10, pp. 158-166, 2005.

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