Optically Driven Micromanipulators with Rotating Arms
Shoji Maruo*,** and Yojiro Hiratsuka*
*Department of Mechanical Engineering, Graduate School of Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya, Yokohama, Kanagawa 240-8501, Japan
**Researcher of Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, 5 Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan
We propose optically controlled micromanipulation tools that operate in sealed environments. The micromanipulator arm has probes to grasp microobjects and a handle to rotate the arm on its long axis. When a laser beam is focused on the handle and scanned linearly on the focal plane, the handle inclines toward the focus, rotating the arm on its long axis for probes to grasp a microobject. Rotation enable the microobject to be grasped separately from a substrate. Micromanipulators, fabricated by using two-photon microstereolithography, can catch microparticles in three dimensions, and a single manipulator arm with twin probes has been used to slide a microparticle on a glass substrate. Such optically controlled micromanipulators are potentially versatile, powerful tools for micro total analysis in biological applications.
-  M. A. Burns, B. N. Johnson, S. N. Brahmasandra, K. Handique, J. R. Webster, M. Krishnan, T. S. Sammarco, P. M. Man, D. Jones, D. Heldsinger, C. H. Mastrangelo, and D. T. Burke, “An Integrated Nanoliter DNA Analysis Device,” Science, Vol.282, pp. 484-487, 1998.
-  T. Thorsen, S. J. Maerkl, and S. R. Quake, “Microfluidic large-scale integration,” Science, Vol.298, pp. 580-584, 2002.
-  A. Y. Fu, H. P. Chou, C. Spence, F. H. Arnold, and S. R. Quake, “An integrated microfabricated cell sorter,” Anal. Chem., Vol.74, pp. 2451-2457, 2002.
-  S. Takayama, E. Ostuni, P. LeDuc, K. Naruse, D. E. Ingber, and G. M. Whitesides, “Laminar flows Subcellular positioning of small molecules,” Nature, Vol.411, p. 1016, 2001.
-  G. Hashiguchi, T. Goda, M. Hosogi, K. Hirano, N. Kaji, Y. Baba, K. Kakushima, and H. Fujita, “DNA Manipulation and Retrieval from an Aqueous Solution with Micromachined Nanotweezers,” Anal. Chem., Vol.75, pp. 4347-4350, 2003.
-  Y. W. Lua and C. J. Kim, “Microhand for biological applications,” Appl. Phys. Lett., Vol.89, 164101, 2006.
-  A. Ashkin, J. M. Dziedzic, J. E. Bjorkholm, and S. Chu, “Observation of a single-beam gradient force optical trap for dielectric particles,” Opt. Lett., Vol.11, pp. 288-290, 1986.
-  S. Maruo, K. Ikuta, and H. Korogi, “Submicron manipulation tools driven by light in a liquid,” Appl. Phys. Lett., Vol.82, pp. 133-135, 2003.
-  S. Maruo, K. Ikuta, and H. Korogi, “Force-controllable, optically driven micromachines fabricated by single-step two-photon microstereolithography,” J. Microelectromech. Syst., Vol.12, pp. 533-539, 2003.
-  Y. Hiratsuka and S. Maruo, “Development of optically controlled micromanipulation systems by using two-photon microstereolithography,” The Transactions of The Institute of Electrical Engineers of Japan, Vol.125-E, No.12, pp. 473-478, 2005.
-  S. Maruo and Y. Hiratsuka, “All optically controlled micromanipulation systems,” Proc. of Micro Total Analysis Systems 2005, pp. 1206-1208, 2005.
-  S. Maruo, O. Nakamura, and S. Kawata, “Three-dimensional microfabrication with two-photon absorbed photopolymerization,” Opt. Lett., Vol.22, pp. 132-134, 1997.
-  S. Kawata, H. B. Sun, T. Tanaka, and K. Takada, “Finer features for functional microdevices,” Nature, Vol.412, pp. 697-698, 2001.
-  P. Galajda and P. Ormos, “Complex micromachines produced and driven by light,” Appl. Phys. Lett., Vol.78, pp. 249-251, 2001.
-  S. Maruo and H. Inoue, “Optically driven micropump produced by three-dimensional two-photon microfabrication,” Appl. Phys. Lett., Vol.89, 144101, 2006.
Copyright© 2007 by Fuji Technology Press Ltd. and Japan Society of Mechanical Engineers. All right reserved.