Henipavirus Infections – An Expanding Zoonosis from Fruit Bats
Chieko Kai and Misako Yoneda
Laboratory of Animal Research Center / International Research Center for Infectious Diseases, Institute of Medical Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
The henipavirus genus has two members – the Hendra virus (HeV) and the Nipah virus (NiV). HeV and NiV, identified in the 1990s as a paramyxovirus, cause fatalities in humans and animals. They are now classified as biosafety level 4 pathogens. HeV caused fatal respiratory infection in horses and humans in Australia in 1994, in which 2 persons died. The first-known, largest NiV outbreak occurred on theMalay Peninsula in 1998, in pigs and humans. The human fatality rate was 40%, killing 105. To cope, the Malaysian government culled over 1 million pigs at huge economic loss. The natural virus reservoir, the fruit bat (Pteropus), inhabits areas from Australia, through South Asia to Africa. InMalaysia, NiV to humans was through pigs, and the reemergence has never observed after that. However, sporadic outbreaks of NiV are continuously occurring in Bangladesh and India, in some of which epidemics human mortality exceeds 75%. The transmission is directly from fruit bats to humans, and even human-to-human transmissions are found. To prevent the outbreaks, it is important to have an intense monitoring for these diseases, to accumulate basic knowledge about the viruses and the diseases, and to develop effective vaccines.
-  L. A. Selvey, R. M. Wells, G. J. McCormack, A. J. Ansford, K. Murray, R. J. Rogers, P. S. Lavercombe, P. Selleck, and J.W. Sheridan, “Infection of humans and horses by a newly described morbillivirus,” Med. J. Aust. 162 (12), pp. 642-645, 1995.
-  K. Murray, B. Eaton, P. Hooper, L. Wang, M. Williamson, and P. Yound, “Flying foxes, horses, and humans: a zoonosis caused by a new member of the paramyxoviridae,” Emerging Infections 1, pp. 43-58, 1998.
-  H. Field, P. Young, J. M. Yob, J. Mills, L. Hall, and J. Mackenzie, “The natural history of Hendra and Nipah viruses,” Microbes Infect. 3 (4), pp. 307-314, 2001.
-  OIE & CFSPH, Iowa State Univ., “Hendra Virus Infection,” pp. 1-7, September, 2009.
-  ProMED mail,
http://promedmail.oracle.com/pls/wwv_flow.accept,Int. Society for Infectious Diseases.
-  K. J. Goh, C. T. Tan, N. K. Chew, P. S. Tan, A. Kamarulzaman, S. A. Sarji, K. T. Wong, B. J. Abdullah, K. B. Chua, and S. K. Lam, “Clinical features of Nipah virus encephalitis among pig farmers in Malaysia,” N. Engl. J. Med., 342, pp. 1229-1235, 2000.
-  K. B. Chua, W. J Bellini, P. A. Rota, B. H. Harcourt, A. Tamin, S.K. Lam, T. G. Ksiazek, P. E. Rolin, S. R. Zaki, W. Shieh, C. S. Goldsmith, D. J. Gubler, J. T. Roehrig, B. Eaton, A. R. Gould, J. Olson, H. Field, P. Daniels, A. E. Lingm, C. J. Peters, L. J. Anderson, and B.W. Mahy, “Nipah virus: A recently emergent deadly paramyxovirus,” Science 288, pp. 1432-1435, 2000.
-  U. D. Parashar, L. M. Sunn, F. Ong, A.W. Mounts, M. T. Arif, T. G. Ksiazek, M. A. Kamaluddin, A. N. Mustafa, H. Kaur, L. M. Ding, G. Othman, H. M. Radzi, P. T. Kitsutani, P.C. Stockton, J. Arokiasamy, H. E. Jr. Gary, and L. J. Anderson, “Case-control study of risk factors for human infection with a novel zoonotic paramyxovirus, Nipah virus, during a 1998-1999 outbreak of severe encephalitis in Malaysia,” J. Infect. Dis., 181, pp.1755-1759, 2000.
-  N. I. Paton, Y. S. Leo, S. R. Zaki, A. P. Auchus, K. E. Lee, A. E. Ling, S.K. Chew, B. Ang, P. E. Rollin, T. Umapathi, I. Sng, C. C. Lee, E. Lim, and T. G. Ksiazek, “Outbreak of Nipah-virus infection among abattoir workers in Singapore,” Lancet, 354(9186), pp. 1253-1256, 1999.
-  B. T. Eaton, C. C. Broder, D. Middleton, and L. F. Wang, “Hendra and Nipah viruses: different and dangerous,” Nat. Rev. Microbiol., 4 (1), pp. 23-35, 2006.
-  V. P. Hsu, M. J. Hossain, U. D. Parashar, M. M. Ali, T. G. Ksaizek, I. Kuzumi, M. Niezgoda, C. Rupprecht, J. Bresee, and R. F. Brieman, “Nipah virus encephalitis reemergence, Bangladesh,” Emerg. Infect. Dis., 10, pp. 2082-2087, 2004.
-  K. J. Goh, C. T. Tan, N. K. Chew, P. S. Tan, A. Kamarulzaman, S. A. Sarji, K. T. Wong, B. J. Abdullah, K. B. Chua, and S. K. Lam, “Clinical features of Nipah virus encephalitis among pig farmers in Malaysia,” N. Engl. J. Med., Vol.342, pp. 1229-1235, 2000.
-  C. T. Tan, K. J. Goh, K. T. Wong, S. A. Sarji, K. B. Chua, N. K., Chew, P. Murugasu, Y. L. Loh, H. T. Chong, K. S. Tan, T. Thayaparan, S. Kumar, and M. R. Jusoh, “Relapsed and late-onset Nipah encephalitis,” Ann Neurol, Vol.51, pp. 703-708, 2002.
-  S. K. Lam, “Nipah virus – a potential agent of bioterrorism?,” Antiviral Research 57, pp. 113-119, 2003.
-  FAO Regional Office for Asia and the Pacific, APHCA, “Manual on the diagnosis of Nipah virus infection in animals,” RAP publication No. 2002/01.
-  H. Hosono, H. Kono, S. Ito, and J. Shirai, “Economic Impact of Nipah Virus Infection Outbreak in Malaysia,” Proc. of the 11th Int. Symposium on Veterinary Epidemiology and Economics, 2006.
-  T. Vu, “Rethinking the traditional concept of livestock sewrvices: A study of response capacity in Thailand, Malaysia ans Vietnam,” PPLPI Workiing paper, FAO, 2007.
-  K. B. Chua, “Nipah virus outbreak in Malaysia,” J. Clin. Virol. Vol.26, pp. 265-275, 2003.
-  K. B. Chua, C. L. Koh, P. S. Hooi, K. F. Wee, J. H. Khong, B. H. Chua, Y. P. Chan, M. E. Lim, and S. K. Lam, “Isolation of Nipahvirus from Malaysian Island flying-foxes,” Microbes Infect. Vol.4, pp. 145-151, 2002.
-  J. N. Mills, A. N. Alim, M.L. Bunning, O. B. Lee, K. D. Wagoner, B. R. Amman, P. C. Stockton, and T. G. Ksiazek, “Nipah virus infection in dogs, Malaysia, 1999,” Emerg. Infect. Dis., 15(6), pp. 950-952, 2009.
-  S. P. Luby, M. Rahman, M. J. Hossain, L. S. Blum, M. M. Husain, E. Gurley, R. Khan, B. N. Ahmed, S. Rahman, N. Nahar, E. Kenah, J. A. Comer, and T. G. Ksiazek, “Foodborne transmission of Nipah virus, Bangladesh,” Emerg. Infect. Dis., 12, pp. 1888-1894, 2006.
-  CDC/WHO, “Biosafety in Microbiological and Biomedical Laboratories, 5 Edition,” 2009.
-  OIE Terrestrial Manual, “Hendra and Nipah Virus Diseases,” Chaper 2.9.6., pp. 1-14, 2010.
-  Y. Kaku, A. Noguchi, G. A. Marsh, J. A. McEachern, A. Okutani, K. Hotta, B. Bazartseren, S. Fukushi, C. C. Broder, A. Yamada, S. Inoue, and L. F. Wang, “A neutralization test for specific detection of Nipah virus antibodies using pseudotyped vesicular stomatitis virus expressing green fluorescent protein,” J. Virol. Methods, 160, pp. 7-13, 2009.
-  H. M.Weingartl, Y. Berhane, J. Caswell, S. Loosmore, J. C. Audonnet, J.A. Roth and M. Czub, “Recombinant Nipah Virus Vaccines Protect Pigs against Challenge,” J. Viol., 80(16), pp. 7929-7938, 2006.
-  M. Yoneda, V. Guillaume, H. F. Ikeda, Y. Sakuma, H. Sato, T. F. Wild, and C. Kai. “Establishment of a Nipah virus rescue system,” Proc. Natl. Acad. Sci., USA, 103(44), pp. 16508-16513, 2006.
-  M. Yoneda, V. Guillaume, H. Sato, K. Fujita, M. C. Georges-Courbot, F. Ikeda, M. Omi, Y. Muto-Terao, T. F. Wild, and C. Kai, “The nonstructural proteins of Nipah virus play a key role in pathogenicity in vivo,” PLoS ONE, 5(9), e12709(1-8), 2010.
-  M. Omi-Furutani, M. Yoneda, K. Fujita, F. Ikeda, and C. Kai, “Novel phosphoprotein-interacting region in Nipah virus nucleocapsid protein and its involvement in viral replication,” J. Virol., pp. 9793-9799, 2010.
-  CDC; Emergency Preparedness and Response,
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