IJAT Vol.11 No.6 pp. 932-940
doi: 10.20965/ijat.2017.p0932


Influence of Early-Stage Hydrolysis on Tensile Fracture Behavior of HAp/PLA Composites Interface-Controlled by Reaction Control Utilizing Photodissociable Protecting Groups

Mototsugu Tanaka*,†, Tomoyuki Takahashi**, and Isao Kimpara***

*Department of Mechanical Engineering, Kanazawa Institute of Technology
Ohgigaoka 7-1, Nonoichi, Japan

Corresponding author

**Kanazawa Institute of Technology, Nonoichi, Japan

***Research Laboratory for Integrated Technological Systems, Kanazawa Institute of Technology, Hakusan, Japan

January 31, 2017
May 9, 2017
Online released:
October 31, 2017
November 5, 2017
HAp/PLA composites, scaffold, interface control, hydrolysis, fracture behavior

In this study, the change in the tensile fracture behavior of HAp/PLA composites, interface-controlled using pectin and chitosan, was evaluated for the case of the early-stage hydrolysis. Here, the reaction between the HAp particles and modification polymers was controlled using o-nitrobenzyl alcohol. Tensile tests after immersion in a pseudo biological environment indicated that the interface-control method employed in this study improved the fracture properties of HAp/PLA composites significantly, inducing the large plastic deformation. In addition, the effects of early-stage hydrolysis on fracture behavior and mechanism are discussed from the viewpoint of interfacial structures for the interface-controlled HAp/PLA composites. Observations of fracture morphologies and surfaces suggest that the interface-control employed in this study successfully improved interfacial bonding, enabling the effective usage of the deformability of the PLA matrix. The interface-control method employed in this study also maximized the fracture strain through the combination of improved interfacial bonding and an increase in the ductility of the PLA matrix after a 2-week immersion. Test results also suggest that the cancelation induced by the degradation of chitosan accelerated the degradation of the PLA matrix after a longer immersion.

Cite this article as:
Mototsugu Tanaka, Tomoyuki Takahashi, and Isao Kimpara, “Influence of Early-Stage Hydrolysis on Tensile Fracture Behavior of HAp/PLA Composites Interface-Controlled by Reaction Control Utilizing Photodissociable Protecting Groups,” Int. J. Automation Technol., Vol.11, No.6, pp. 932-940, 2017.
Data files:
  1. [1] G. Ryan, A. Pandit, and D.P. Apatsidis, “Fabrication methods of porous metals for use in orthopaedic applications,” Biomaterials, Vol.27, pp. 2651-2670, 2006.
  2. [2] R. Langer and J. P. Vacanti, “Tissue engineering,” Science, Vol.260, pp. 920-926, 1993.
  3. [3] D. W. Hutmache, “Scaffolds in tissue engineering bone and cartilage,” Biomaterials, Vol.21, pp. 2529-2543, 2000.
  4. [4] M. Kellomäki, H. Niiranen, K. Puumanen, N. Ashammakhi, T. Waris, and P. Törmälä, “Bioabsorbable scaffolds for guided bone regeneration and generation,” Biomaterials, Vol.21, pp. 2495-2505, 2000.
  5. [5] T. Adachi, Y. Osako, M. Tanaka, M. Hojo, and S.J. Hollister, “Framework for optimal design of porous scaffold microstructure by computational simulation of bone regeneration,” Biomaterials, Vol.27, pp. 3964-3972, 2006.
  6. [6] U. Chung and Y. Tei, “Manufacturing of artificial bones using 3D inkjet printing technology,” Int. J. of Automation Technology, Vol.3, pp. 509-513, 2009.
  7. [7] A. Rouzrokh, C. Yi-HsuanWei, K. Erkorkmaz, and R. M. Pilliar, “Machining porous calcium polyphosphate implants for tissue engineering applications,” Int. J. of Automation Technology, Vol.4, pp. 291-302, 2010.
  8. [8] N. Ignjatović, S. Tomić, M. Dakić, M. Miljković, M. Plavšić, and D. Uskoković, “Synthesis and properties of hydroxyapatite/ poly-l- lactide composite biomaterials,” Biomaterials, Vol.20, pp. 809-816, 1999.
  9. [9] Y. Shikinami and M. Okuno, “Bioresorbable devices made of forged composites of hydroxyapatite (HA) particles and poly-L-lactide (PLLA): Part I. Basic characteristics,” Biomaterials, Vol.20, pp. 859-877, 1999.
  10. [10] G. Wei and P.X. Ma, “Structure and properties of nano- hydoxyapatite/polymer composite scaffolds for bone tissue engineering,” Biomaterials, Vol.25, pp. 4749-4757, 2004.
  11. [11] M. Todo, S.D. Park, K. Arakawa, and Y. Takenoshita, “Relationship between microstructure and fracture behavior of bioabsorbable HA/PLLA composites,” Composites, A, Vol.37, pp. 2221-2225, 2006.
  12. [12] S. Kobayashi and K. Sakamoto, “Effects of crystallinity on the mechanical properties of TCP/PLLA composites,” J. of Solid Mechanics and Materials Engineering, Vol.2, pp. 1232-1241, 2008.
  13. [13] S. Yamadi and S. Kobayashi, “Effects of strain rate on the mechanical properties of tricalcium phosphate/poly(L-lactide) composites,” J. of Materials Science: Materials in Medicine, Vol.20, pp. 67-74, 2009.
  14. [14] S. Kobayashi and K. Sakamoto, “Effect of hydrolysis on mechanical properties of tricalcium phosphate/poly-L-lactide composites,” J. of Materials Science: Materials in Medicine, Vol.20, pp. 379-386, 2009.
  15. [15] S. Kobayashi and K. Sakamoto, “Bending and compressive properties of crystallized TCP/PLLA composites,” Advanced Composite Materials, Vol.18, pp.287-295, 2009.
  16. [16] S. Kobayashi and S. Yamadi, “Strain rate dependency of mechanical properties of TCP/PLLA composites after immersion in simulated body environments,” Composite science and Technology, Vol.70, pp. 1820-1825, 2010.
  17. [17] T. Nishino, M. Kotera, M. Sugihara, H. Tanaka, M. Tanaka, T. Adachi, and M. Hojo, “Interfacial control and mechanical properties of poly-L-lactic acid/hydroxyapatite composite,” Polymers Preprints, Japan, Vol.56, p. 2216, 2007, in Japanese.
  18. [18] M. Tanaka, H. Tanaka, M. Hojo, T. Adachi, M. Sugihara, M. Kotera, and T. Nishino, “Change in deformation/fracture behavior of interface-controlled HAp/PLLA composites by hydrolysis,” Proc. of the 17th Internationa Conf. on Composite Materials, CD-ROM, 2009.
  19. [19] M. Tanaka, Y. Tsuda, R. Yasada, and I. Kimpara, “Trial of hybrid interface control In HAp/PLA composites,” Proc. of 15th European Conf. on Composite Materials, CD-ROM, 2012.
  20. [20] M. Tanaka, R. Yasuda, Y. Tsuda, and I. Kimpara, “Proposal of novel interface-control method in HAp/PLA composites for bone regeneration by reaction-control utilizing photodissociable protection groups,” Materials System, Vol.34, pp. 45-49, 2016, in Japanese.

*This site is desgined based on HTML5 and CSS3 for modern browsers, e.g. Chrome, Firefox, Safari, Edge, Opera.

Last updated on Feb. 25, 2021