IJAT Vol.11 No.6 pp. 878-882
doi: 10.20965/ijat.2017.p0878


Surface Microfabrication of Conventional Glass Using Femtosecond Laser for Microfluidic Applications

Takuma Niioka and Yasutaka Hanada

Hirosaki University
3 Bunkyo-cho, Hirosaki, Aomori 036-8561, Japan

Corresponding author

January 24, 2017
June 14, 2017
Online released:
October 31, 2017
November 5, 2017
femtosecond laser, microfabrication, glass microfluidics, fluorescent microscopic observation

Recently, a lot of attention has been paid to a single-cell analysis using microfluidic chips, since each cell is known to have several different characteristics. The microfluidic chip manipulates cells and performs high-speed and high-resolution analysis. In the meanwhile, femtosecond (fs) laser has become a versatile tool for the fabrication of microfluidic chips because the laser can modify internal volume solely at the focal area, resulting in three-dimensional (3D) microfabrication of glass materials. However, little research on surface microfabrication of materials using an fs laser has been conducted. Therefore, in this study, we demonstrate the surface microfabrication of a conventional glass slide using fs laser direct-writing for microfluidic applications. The fs laser modification, with successive wet etching using a diluted hydrofluoric (HF) acid solution, followed by annealing, results in rapid prototyping of microfluidics on a conventional glass slide for fluorescent microscopic cell analysis. Fundamental characteristics of the laser-irradiated regions in each experimental procedure were investigated. In addition, we developed a novel technique combining the fs laser direct-writing and the HF etching for high-speed and high-resolution microfabrication of the glass. After establishing the fs laser surface microfabrication technique, a 3D microfluidic chip was made by bonding the fabricated glass microfluidic chip with a polydimethylsiloxane (PDMS) polymer substrate for clear fluorescent microscopic observation in the microfluidics.

Cite this article as:
T. Niioka and Y. Hanada, “Surface Microfabrication of Conventional Glass Using Femtosecond Laser for Microfluidic Applications,” Int. J. Automation Technol., Vol.11, No.6, pp. 878-882, 2017.
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