On-Demand Production of Emulsion Droplets Using  Magnetically Driven  Microtool

Yoko Yamanishi; Yuki Kihara; Shinya Sakuma; Fumihito Arai

doi:10.20965/ijat.2009.p0502

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IJAT Vol.3 No.5 pp. 502-508

doi: 10.20965/ijat.2009.p0502

(2009)

Paper:

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On-Demand Production of Emulsion Droplets Using Magnetically Driven Microtool

Yoko Yamanishi, Yuki Kihara, Shinya Sakuma, and Fumihito Arai

Department of Bioenginering and Robotics, Tohoku University, 6-6-01 Aramaki-Aza-Aoba, Aoba-ku, Sendai, Miyagi-ken 980-8579, Japan

Received:

June 12, 2009

Accepted:

July 27, 2009

Published:

September 5, 2009

Keywords:

μTAS, droplet dispensing, magnetically driven microtool, encapsulation, multiphase flow

Abstract

We propose a hybrid polymer-metal magnetically driven microtool (MMT) featuring elasticity and rigidity. An electroplated magnetic metal axle is installed directly at the center of the MMT during molding. The result is a hybrid MMT whose fixed axes move elastically in a specific direction and whose center axle is rigid, preventing bending by unwanted external force. The axle’s higher magnetism contributes to powerful actuation. The hybrid MMT we designed provides on-demand droplet dispensation on chips. Its parallel plate is constrained translationally. Hybrid MMT displacement is 300 μm - 6 times greater than that of the conventional MMT. On-demand droplet generation produces a 177.7 ±2.3 μm droplet.

Cite this article as:

Y. Yamanishi, Y. Kihara, S. Sakuma, and F. Arai, “On-Demand Production of Emulsion Droplets Using Magnetically Driven Microtool,” Int. J. Automation Technol., Vol.3 No.5, pp. 502-508, 2009.

Data files:

References

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[7] C-W. Lai, Y-H. Lin, and G-B. Lee, “A microfluidic chip for formation and collection of emulsion droplets utilizing active pneumatic micro-choppers and micro-switches,” Biomedical Microdevices, 10, pp. 749-756, 2008.
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[14] I. Kobayashi, K. Uemura, and M. Nakajima, “Controlled Generation of Mono-disperse Discoid Droplets Using Microchannel Arrays,” Langmuir, 22, 10893-10897, 2006.
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[16] C-H Lee, S-K Hsiung, and G-B Lee, “An Active Flow Focusing Microfluidic Chip Utilizing Controllable Moving Walls for the Formation of Microdroplets in Liquid,” Proc. of the 2^nd IEEE Int. Conf. on Nano/Micro Engineering and Molecular systems, pp. 167-171, 2007.
[17] Y. C. Tan and A. P. Lee, “Microfluidic separation of satellite droplets as the basis of a monodispersed micron and submicron emulsification system,” Lab on a Chip, 5, No.10, pp. 1178-1183, 2005.
[18] Y. Yamanishi, Y. C. Lin, and F. Arai, “Magnetically Modified PDMS Devices for Active Microfluidic Control,” μ-TAS2007, pp. 883-885, 2007.
[19] Y. Yamanishi, S. Sakuma, and F. Arai, “Magnetically Modified Soft Micro Actuator for Oocyte Manipulation,” IEEE Int. Symposium on Micromechatronics and Human Science (MHS), pp. 442-447, 2007.
[20] Y. Yamanishi, Y. C. LIN, and F. Arai, “Magnetically modified PDMD microtools for micro particle manipulation,” Proc. of the 2007 IEEE/RSJ Int. Conf. on Intelligent Robotics and Systems, pp. 753-758, 2007.
[21] Y. Yamanishi, S. Sakuma, and F. Arai, “High-accuracy Polymer-based Magnetically Driven Microtool Production and Application,” Journal of Robotics and Mechatronics, Vol.20, No.2, pp. 273-279, 2008.
[22] Y. Yamanishi, S. Sakuma, K. Onda, and F. Arai, “Biocompatible Polymeric Magnetically Driven Microtool for Particle Sorting,” Journal of Micro and Nano Mechatronics, Vol.4, No.1, pp. 49-57, 2008.
[23] Y. Yamanishi, Y. Kihara, S. Sakuma, and F. Arai, “On-chip Droplet Dispensing by Magnetically Driven Microtool,” Journal of Robotics and Mechatronics, Vol.21, No.2, pp. 229-235, 2009.
[24] Rikanenpyo (Chronological Scientific Tables), edited by National Astronomic Observatory Japan (Maruzen, Tokyo), 2007.
[25] Y. Tanaka, K. Morishima, T. Shimizu, A. Kikuchi, M. Yamato, T. Okanobe, and T. Kitamori, “Demonstration of a PDMS-based bio-microactuator using cultured cardiomyocytes to drive polymer micropillars,” Lab on a chip, 6, pp. 230-235, 2006.

This article is published under a Creative Commons Attribution-NoDerivatives 4.0 Internationa License.

[1] [1] P. Garstecki, H. A. Stone, and G. M. Whiteside, “Mechanism for Flow-Rate Controlled Breakup in Confined Geometries: A Route to Monodisperse Emulsions,” Physical Review Letter, Vol.94, No.164501, 2005.

[2] [2] S-Y Teh, R. Lin, L-H Hung, and A. P. Lee, “Droplet microfluidics,” Lab on a chip, Vol.8, pp. 198-220, 2008.

[3] [3] C. Charcosset, I. Limayem, and H. Fessi, “The membrane emulsification process - a review,” Journal of Chemical Technology and Biotechnology, Vol.79, pp. 209-218, 2004.

[4] [4] A.V. Korobko, W. Jesse, and J. R. C. Van der Maarel, “Encapsulation of DNA by Cationic Diblock Copolymer Vesicles,” Vol.21, pp. 34-42, 2005.

[5] [5] S. M. Moghimi, A. C. Hunter, and J. C. Murray, “Nanomedicine: current status and future prospects,” The FASEB Journal 19, pp. 311-330, 2005.

[6] [6] T. Kojima, Y. Takei, M. Ohtsuka, Y. Kawarasaki, T. Yamane, and H. Nakano, “PCR amplification from single DNA molecules on magnetic beads in emulsion: application for high-throughput creening of transcrption factor targets,” Nucleic Acids Research, Vol.33 (17), e150.

[7] [7] C-W. Lai, Y-H. Lin, and G-B. Lee, “A microfluidic chip for formation and collection of emulsion droplets utilizing active pneumatic micro-choppers and micro-switches,” Biomedical Microdevices, 10, pp. 749-756, 2008.

[8] [8] G. T. Vladisavljevic and H. Schubert, “Preparation and analysis of oil-in-water emulsions with a narrow droplet size distribution using Shirasu-porous-glass (SPG) membranes,” Desalination 144, pp. 167-172, 2002.

[9] [9] C-T. Chen and G-B. Lee, “Formation of microdroplets in liquids utilizing active pneumatic choppers on a microfluidic chip,” Journal of microelectromechanical systems, Vol.15 (6), pp. 1492-1498, 2006.

[10] [10] T. Nisisako, T. Torii, and T. Higuchi, “Novel microreactors for functional polymer beads,” Chemical Engineering Journal, Vol.101, pp. 23-29, 2004.

[11] [11] Q. Lu, Z. Weng, G. Shan, G. Lai, and Z. Pan, “Effect of Acrylonitrile Water Solubility on the Suspension Copolymerization of Acrylonitrile and Styrene,” Journal of Applied Polymer Science, Vo101, pp. 4270-4274, 2006.

[12] [12] M. Seo, C. Paquet, Z. Nie, S. Xu, and E. Kumacheva, “Microfluidic consecutive flow-focusing droplet generators,” Lab on a chip, Vol.3, pp. 986-992, 2007.

[13] [13] D. R. Link, S. L. Anna, D. A. Weitz, and H. A. Stone, “Geometrically Meditated Breakup of Drops in Microfluidic Devices,” Physical Review Letter, Vol.92, No.054503, 2004.

[14] [14] I. Kobayashi, K. Uemura, and M. Nakajima, “Controlled Generation of Mono-disperse Discoid Droplets Using Microchannel Arrays,” Langmuir, 22, 10893-10897, 2006.

[15] [15] S-Y Teh, R. Lin, L-H Hung, and A. P. Lee, “Droplet microfluidics,” Lab on a chip, Vol.8, pp. 198-220, 2008.

[16] [16] C-H Lee, S-K Hsiung, and G-B Lee, “An Active Flow Focusing Microfluidic Chip Utilizing Controllable Moving Walls for the Formation of Microdroplets in Liquid,” Proc. of the 2^nd IEEE Int. Conf. on Nano/Micro Engineering and Molecular systems, pp. 167-171, 2007.

[17] [17] Y. C. Tan and A. P. Lee, “Microfluidic separation of satellite droplets as the basis of a monodispersed micron and submicron emulsification system,” Lab on a Chip, 5, No.10, pp. 1178-1183, 2005.

[18] [18] Y. Yamanishi, Y. C. Lin, and F. Arai, “Magnetically Modified PDMS Devices for Active Microfluidic Control,” μ-TAS2007, pp. 883-885, 2007.

[19] [19] Y. Yamanishi, S. Sakuma, and F. Arai, “Magnetically Modified Soft Micro Actuator for Oocyte Manipulation,” IEEE Int. Symposium on Micromechatronics and Human Science (MHS), pp. 442-447, 2007.

[20] [20] Y. Yamanishi, Y. C. LIN, and F. Arai, “Magnetically modified PDMD microtools for micro particle manipulation,” Proc. of the 2007 IEEE/RSJ Int. Conf. on Intelligent Robotics and Systems, pp. 753-758, 2007.

[21] [21] Y. Yamanishi, S. Sakuma, and F. Arai, “High-accuracy Polymer-based Magnetically Driven Microtool Production and Application,” Journal of Robotics and Mechatronics, Vol.20, No.2, pp. 273-279, 2008.

[22] [22] Y. Yamanishi, S. Sakuma, K. Onda, and F. Arai, “Biocompatible Polymeric Magnetically Driven Microtool for Particle Sorting,” Journal of Micro and Nano Mechatronics, Vol.4, No.1, pp. 49-57, 2008.

[23] [23] Y. Yamanishi, Y. Kihara, S. Sakuma, and F. Arai, “On-chip Droplet Dispensing by Magnetically Driven Microtool,” Journal of Robotics and Mechatronics, Vol.21, No.2, pp. 229-235, 2009.

[24] [24] Rikanenpyo (Chronological Scientific Tables), edited by National Astronomic Observatory Japan (Maruzen, Tokyo), 2007.

[25] [25] Y. Tanaka, K. Morishima, T. Shimizu, A. Kikuchi, M. Yamato, T. Okanobe, and T. Kitamori, “Demonstration of a PDMS-based bio-microactuator using cultured cardiomyocytes to drive polymer micropillars,” Lab on a chip, 6, pp. 230-235, 2006.