3D 6DOF Manipulation of Microbead by Laser Tweezers
Fumihito Arai*, Toshiaki Endo**, Ryuji Yamauchi**,
and Toshio Fukuda**
*Department of Bioengineering and Robotics, Tohoku University, 6-6-01 Aramaki-Aoba, Aoba-ku, Sendai 980-8579, Japan
**Department of Micro-Nano Systems Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
Laser tweezers are suitable for manipulation of a single microscopic biological object. It can manipulate micro bio-object by noncontact in closed space. Single cell manipulation is important for biological research works, and 3D 6DOF manipulation (Position control and Orientation control) is useful technique in many biological experiments. Here we proposed 3D synchronized laser manipulation system by which we can manipulate multiple micro-objects along each designed trajectory in 3D space. Position and orientation of microbeads can be controlled by the newly developed 3D synchronized laser micromanipulation system. We succeeded in the orientation control of the microbead by using the laser trapped microtools. We demonstrate 3D 6DOF manipulation of the microbead by the experiment.
-  A. Fuchs, “A microelectronic chip opens new fields in rare cell population analysis and individual cell biology,” Proc. Micro Total Analysis system, California, USA, pp. 911-914, 2003.
-  G. Fuhr, U. Zimmermann, and S. G. Shirley, “Chapter 5 Cell Motion in Time-Varying Fields: Principles and Potential,” Electromanipulation of Cells, CRC Press, pp. 259-328, 1996.
-  A. Kawaji, F. Arai, and T. Fukuda, “Positional Recognition and Attitude Control for 3-D Biomicromanipulation in Microscopy,” Journal of Robotics and Mechatronics, Vol.14, No.3, pp. 238-244, 2002.
-  A. Ashkin, “Acceleration and trapping of particles by radiation pressure,” Phys. Rev. Lett., Vol.24, pp. 156-159, 1970.
-  A. Ashkin, and J. M. Dziedzic, “Optical Trapping and Manipulation of Viruses and Bacteria,” Science, Vol.235, pp. 1517-1520, 1987.
-  D. G. Grier, “A Revolution in optical manipulation,” Nature, Vol.424, pp. 810-816, 2003.
-  K. Sasaki, M. Koshioka, H. Misawa, H. Kitamura, and H. Masuhara, “Pattern formation and Flow control of fine particles by laser-scanning micromanipulation,” Opt. Lett., Vol.16, p. 1463, 1991.
-  P. J. Rodrigo, V. R. Daria, and J. Glucksted, “Real-time threedimensional optical micromanipulation of multiple particles and living cells,” Optics Letters, Vol.29, No.19, pp. 2270-2272, 2004.
-  L. Paterson, M. P. MacDonald, J. Arlt, W. Sibbett, P. E. Bryant, and K. Dholakia, “Controlled rotation of optically trapped microscopic particles,” Science, Vol.292, pp. 912-914, 2001.
-  E. Higurashi, R. Sawada, and T. Ito, “Optically induced rotation of a trapped micro-object about an axis perpendicular to the laser beam axis,” Applied Physics Letters, Vol.72, No.23, pp. 2951-2953, 1998.
-  H. Liang et al., “Wavelength Dependence of Cell Cloning Efficiency after Optical Trapping,” Biophysical Journal, Vol.70, pp. 1529-1533, 1996.
-  F. Arai et al., “High Speed Random Separation of Microobject in Microchip by Laser Manipulation and Dielectrophoresis,” Proc. of MEMS’2000, pp. 727-732, 2000.
-  F. Arai, H. Maruyama, T. Sakami, A. Ichikawa, and T. Fukuda, “Pinpoint injection of microtools for minimally invasive micromanipulation of microbe by laser trap,” IEEE/ASME Transactions on Mechatronics, Vol.8, No.1, pp. 3-9, 2003.
-  F. Arai, T. Sakami, K. Yoshikawa, H. Maruyama, and T. Fukuda, “Synchronized Laser Micro-manipulation of Microtools for Assembly of Microbeads and Indirect Manipulation of Microbe,” Proc. of the 2003 IEEE/RSJ Int’l Conf. on Intelligent Robot and Systems, pp. 2121-2126, 2003.
-  F. Arai, K. Yoshikawa, T. Sakami, and T. Fukuda, “Synchronized laser micromanipulation of multiple targets along each trajectory by single laser,” Applied Physics Letters, Vol.85, No.19, pp. 4301-4303, 2004.
-  H. Maruyama, F. Arai, T. Fukuda, and T. Katsuragi, “Immobilization of individual cells by local photo polymerization on a chip,” The Analyst, Vol.130, No.3, pp. 304-310, 2005.
-  A. J. Goldman, R. G. Coxs, and H. Brennner, “Slow viscous motion of a sphere parallel to a plane wall-II Couette flow,” Chem. Eng. Sci, Vol.22, No.4, pp. 653-660, 1967.
This article is published under a Creative Commons Attribution-NoDerivatives 4.0 Internationa License.
Copyright© 2006 by Fuji Technology Press Ltd. and Japan Society of Mechanical Engineers. All right reserved.