The phreatic eruption of the Ontake volcano in 2014 reminded us that even moderately active volcanoes, most of which are tourist attractions in Japan, can sometimes exhibit unpredictable and hazardous behaviors, taking away the lives of those who do not fully recognize their threat. With this adding momentum, the Japanese people want volcanology and its applications to be developed to further improve the precision of volcanic eruption alerts. To meet this expectation, a comprehensive program, the “Integrated program for next-generation volcano research and human resource development,” sponsored by the Ministry of Education, Culture, Sports, Science and Technology, was started in November 2016 on a 10-years plan. The most stunning aspect of this program is the integration of (1) a research project and (2) a human resource development program to mitigate volcanic disasters in Japan from long-term point of view. Both of these are collaboratively supported by many researchers from almost all Japanese universities and national institutions related to volcanology. This special issue compiles several topics in this research project to demonstrate its present stage of development and to indicate its anticipated future destination. The target of the research project is to develop, using multi-disciplinary scientific methods, new ways of evaluating volcanic hazards. Specifically, four research groups jointly (A) construct a data archive and exchange system connecting all Japanese volcanologists, (B) develop new geophysical and geochemical observation techniques and methods of analyzing data, (C) evolve methods of predicting volcanic eruptions based on eruption history from precise geological survey and numerical simulations, and (D) propose the provision of technologies for volcanic disasters. We hope that this program will greatly help to mitigate volcanic disasters in Japan, and we will strive to realize this through the research project.