JDR Vol.9 No.5 pp. 784-792
doi: 10.20965/jdr.2014.p0784


Japan-Thailand Collaboration Research on Infectious Diseases: Promotion and Hurdles

Shigeyuki Hamada*,**, Naokazu Takeda*,**, and Taroh Kinoshita*

*Japan-Thailand Collaboration Center, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan

**Thailand-Japan Collaboration Center on Emerging and Re-emerging Infections, Department of Medical Sciences, Ministry of Public Health, Tiwanon Road, Muang, Nonthaburi 11000, Thailand

March 11, 2014
June 12, 2014
October 1, 2014
infectious disease, Japan-Thailand, collaboration research, unexpected incident, J-GRID

The Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections (RCC-ERI) was established in 2005 by the Research Institute for Microbial Diseases (RIMD), Osaka University, in collaboration with the National Institute of Health (NIH), Department of Medical Sciences (DMSc), Ministry of Public Health (MOPH), Thailand. This was initiated based on the recognition that, with today’s highly developed transportation networks including those between Japan and Thailand, infectious disease outbreak and transmission are no longer limited to a single country. Indeed, such diseases are likely to be transmitted immediately to a third country. This makes it essential to cooperate globally in exchanging information fast and often. A dozen Japanese researchers are working regularly at RCC-ERI, where they conduct joint research with Thai researchers on bacterial and viral infectious diseases prevailing in Thailand that could conceivably affect Japan. Examples of such diseases include cholera, meningitis with Streptococcus suis, AIDS, chikungunya fever, and dengue fever. Conducting long-term research in other countries often reveals gaps in perception due to differences in national laws and regulations, in rules and operating customs within research institutions, in economic and cultural backgrounds, and in values and ways of thinking among individual researchers. RCCERI is being operated as fine adjustments are made to achievemaximumproductivity and developing human resources. Some of the many researchers stationed at the Center faced unpredicted situations such as social chaos due to political instability or evacuation due to flooding and had to take emergency response measures. In this article, we cover aspects related to these experiences.

Cite this article as:
Shigeyuki Hamada, Naokazu Takeda, and Taroh Kinoshita, “Japan-Thailand Collaboration Research on Infectious Diseases: Promotion and Hurdles,” J. Disaster Res., Vol.9, No.5, pp. 784-792, 2014.
Data files:
  1. [1] Y. Takeda, “Emerging and reemerging infectious diseases, past, present and future,” J. Disas. Res., Vol.2, pp. 66-70, 2007.
  2. [2] D. M. Morens and A. S. Fauci, “Emerging infectious diseases in 2012: 20 years after the Institute of Medicine report,” mBio, Vol.3, No.6, 2012.
  3. [3] M. J. Mahan, J. Z. Kubicek-Sutherland, and D. M. Heithof, “Rise of the microbes,” Virulence, Vol.4, pp. 213-222, 2013.
  4. [4] E. J. Barzilay, N. Schaad, R. Magloire, K. S. Mung, J. Boncy, G. A. Dahourou, E. D. Mintz, M. W. Steenland, J. E. Vertefeuille, and J. W. Tappero, “Cholera surveillance during the Haiti epidemic – the first 2 years,” New Eng. J. Med., Vol.368, pp. 599-609, 2013.
  5. [5] D. Lantagne, G. B. Nair, C. F. Lanata, and A. Cravioto, “The cholera outbreak in Haitii: Where and how did it begin?” Curr. Top. Microbiol. Immunol., Vol.379, pp. 145-164, 2014.
  6. [6] J. M. Barry, “The great influenza: The epic story of the deadliest plague in history,” Viking Penguin, New York, 2004.
  7. [7] J. Pepin, “The origins of AIDS,” Cambridge University Press, Cambridge, UK, 2011.
  8. [8] M. L. Cohen, “Changing patterns of infectious disease,” Nature, Vol.406, pp. 762-767, 2000.
  9. [9] M. Braks, R. van Ginkel, W. Wint, L. Sedda, and H. Spong, “Climate change and public health policy: Translating the science,” Int. J. Environ. Res. Pub. Health, Vol.11, pp. 13-29, 2014.
  10. [10] Riken Yokohama Institute. “Program of founding research centers for emerging and reemerging infectious diseases,” 2009.
  11. [11] Y. Porapakkham, C. Rao, J. Pattaraarchachai, W. Polprasert, T. Vos, T. Adair, and A. D. Lopez, “Estimated causes of death in Thailand, 2005:implications for health policy,” Popul. Health. Metr., Vol.8, No.14, 2010.
  12. [12] S. Aungkulanon, M. McCarron, J. Lertiendumrong, S. J. Olsen, and K. Bundhamcharoen, “Infectious disease mortality rates, Thailand, 1958-2009,” Emerg. Infect. Dis., Vol.18, pp. 1794-1801, 2012.
  13. [13] D. L. Chao, S. B. Halstead, M. E. Halloran, and I. M. Longini, Jr., “Controlling dengue with vaccines in Thailand,” PLoS Negl. Trop. Dis., Vol.6, pp. e1876, 2012.
  14. [14] C. Caglioti, E. Lalle, C. Castilletti, F. Carletti, M. R. Capobianchi, and L. Bordi, “Chikungunya virus infection: an overview,” New Microbiol., Vol.36, pp. 211-227, 2013.
  15. [15] Ministry of Education, Culture, Sports, Science and Technology “Japan initiative for global research network on infectious diseases, J-GRID,” MEXT, Tokyo, and RIKEN, Yokohama, Japan, 2014.
  16. [16] J. B. Harris, R. C. LaRocque, F. Qadri, E. T. Ryan, and S. B.Calderwood, “Cholera,” Lancet, Vol.379, pp. 2466-2476, 2012.
  17. [17] A. Sterk, J. Schijven, T. de Nijs, and A. M. de Roda Husman, “Direct and indirect effects of climate change on the risk of infection by water-transmitted pathogens,” Environ. Sci. Technol., Vol.47, pp. 12648-12660, 2013.
  18. [18] K. Okada, S. Chantaroj, T. Taniguchi, Y. Suzuki, A. Roobthaisong, O. Puiprom, T. Honda, and P. Sawanpanyalert, “A rapid, simple, and sensitive loop-mediated isothermal amplification method to detect toxigenic Vibrio cholerae in rectal swab samples,” Diagn. Microbiol. Infect. Dis., Vol.66, pp. 135-139, 2010.
  19. [19] K. Okada, A. Roobthaisong, I. Nakagawa, S. Hamada, and S. Chantaroj, “Genotypic and PFGE/MLVA analyses of Vibrio cholerae O1: Geographical spread and temporal changes during the 2007-2010 cholera outbreaks in Thailand,” PLoS One, Vol.7, pp. e30863, 2012.
  20. [20] K. Okada, A. Roobthaisong, W. Swaddiwudhipong, S. Hamada, and S. Chantaroj, “Vibrio cholerae O1 isolate with novel genetic background, Thailand-Myanmar,” Emerg. Infect. Dis., Vol.19, pp. 1015-1017, 2013.
  21. [21] K. Okada, M. Na-Ubol, W. Natakuathung, A. Boobthaisong, F. Maruyama, I. Nakagawa, S. Chantaroj, and S. Hamada, “Comparative genomic characterization of a Thailand-Myanmar isolate, MS6, of Vibrio cholerae O1 el Tor, which is phylogenetically related to a “US Gulf Coast” clone,” PLoS One, Vol.9, pp. e98120, 2014.
  22. [22] T. Sekizaki, “Streptococcus suis : an emerging biothreat,” J. Disas. Res., Vol.7, pp. 303-312, 2012.
  23. [23] M. Okura, D. Takamatsu, F. Maruyama, T. Nozawa, I. Nakagawa, M. Osakai, T. Sekizaki, M. Gottschalk, Y. Kumagai, and S. Hamada, “Genetic analysis of capsular polysaccharide synthesis gene clusters from all serotypes of Streptococcus suis: potential mechanisms for generation of capsular variation,” Appl. Environ. Microbiol., Vol.79, pp. 2796-2806, 2013.
  24. [24] Kerdsin, K. Oishi, S. Spipakdee, N. Boonkerd, P. Polwaichai, S. Nakamura, R. Uchida, P. Sawapanyalert, and S. Dejsirilert, “Clonal dissemination of human isolates of Streptococcus suis serotype 14 in Thailand,” J. Med. Microbiol., Vol.56, pp. 1508-1513, 2009.
  25. [25] A. Kerdsin, S. Dejsirilert, P. Puangpatra, S. Spipakdee, K. Chumia, N. Boonkerd, P. Polwichai, S. Tanimura, D. Takeuchi, T. Nakayama, S. Nakamura, Y. Akeda, M. Gottscalk, P. Sawanpanyalert, and K. Oishi, “Genotypic profile of Streptococcus suis serotype 2 and clinical features of infection in humans, Thailand,” Emerg. Infect. Dis., Vol.17, pp. 835-842, 2011.
  26. [26] S. Wangkaew, R. Chaiwarith, P. Tharavichitkul, and K. Supparatpinyo, “Streptococcus suis infection: a series of 42 cases from Chiang Mai University Hospital,” J. Infect., Vol.52, pp. 455-460, 2006.
  27. [27] D. Takeuchi, A. Kerdsin, A. Pienpringam, P. Loetthong, S. Samerchea, P. Luangsuk, K. Khamisara, N. Wongwan, P. Areeratana, et al., “Population-based study of Streptococcus suis infection in humans in Phayao province in northern Thailand,” PLoS One, Vol.7, pp. e31265, 2012.
  28. [28] P. Utachee, P. Jinnopat, P. Isarangkura-Na-Ayuthaya, U. C. de Silva, S. Nakamura, U. Siripanyaphinyo, N. Wichukchinda, K. Tokunaga, T. Yasunaga, P. Sawanpanyalert, K. Ikuta, W. Auwanit, and M. Kameoka, “Genotypic characterization of CRF01_AE env genes derived from human immunodeficiency virus type 1-infected patients residing in central Thailand,” AIDS Res. Hum. Retroviruses, Vol.25, pp. 229-236, 2009.
  29. [29] P. Utachee, P. Jinnopat, P. Isarangkura-Na-Ayuthaya, U. C. de Silva, S. Nakamura, U. Siripanyaphinyo, N. Wichukchinda, K. Tokunaga, T. Yasunaga, P. Sawanpanyalert, K. Ikuta, W. Auwanit, and M. Kameoka, “Phenotypic studies on recombinant human immunodeficiency virus type 1 (HIV-1) containing CRF01 AE env gene derived from HIV-1-infected patient, residing in central Thailand,” Microb. Infect., Vol.11, pp. 334-343, 2009.
  30. [30] P. Utachee, S. Nakamura, P. Isaranngkura-Na-Ayuthaya, K. Tokunaga, P. Sawanpanyalert, K. Ikuta, W. Auwanit, and M. Kameoka, “Two N-linked glycosylation sites in the V2 and C2 regions of human immunodeficiency virus type 1 CRF01_AE envelope glycoprotein gp120 regulate viral neutralization susceptibility to the human monoclonal antibody specific for the CD4 binding domain,” J. Virol., Vol.84, pp. 4311-4320, 2010.
  31. [31] S. Thiberville, N. Moyen, L. Dupuis-Maguiraga, N. Antoine, E. A. Gould, P. Roques, and X. de Lamballerie, “Chikungunya fever: epidemiology, clinical syndrome, pathogenesis and therapy,” Antiviral Res., Vol.99, pp. 345-370, 2013.
  32. [32] F. J. Burt,M. S. Rolph, N. E. Rulli, S.Mahalingam, andM. T. Heise, “Chikungunya: a re-emerging virus,” Lancet, Vol.379, pp. 662-671, 2011.
  33. [33] N. Kishishita, N. Takeda, A. Anuegoonpipat, and S. Anantapreecha, “Development of a pseudotyped lentiviral vector-based neutralization assay for chikungunya virus infection,” J. Clin. Microbiol., Vol.51, pp. 1389-1395, 2013.

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