Diagnosis System for Predicting the Centrosome Hyperamplification in Bladder Cancer by Using DNA Microarray Data
Kazuhiro Tokunaga*, Fumiya Kubosaka**, Noriaki Suetake**,
Eiji Uchino*,**, and Hideyasu Matsuyama***
*Fuzzy Logic Systems Institute, 680-41 Kawazu, Iizuka, Fukuoka 820-0067, Japan
**Graduate School of Science and Engineering, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8512, Japan
***Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-kogushi, Ube 755-8505, Japan
In this paper, we propose a Computer Aided Diagnosis (CAD) system using a DNA microarray data for an early detection of a bladder cancer. In previous works, it is reported that one of the generating factors of the cancer cells is a centrosome hyperamplification. The centrosome hyperamplification is caused by a damage of DNA. Therefore, it is possible to detect the cancer by using the DNA microarray data. In this paper, the CAD system implemented based on a stochastic approach is proposed. The effectiveness of the present system is verified by the actual experiments.
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