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JACIII Vol.17 No.2 pp. 244-251
doi: 10.20965/jaciii.2013.p0244
(2013)

Paper:

Diagnosis System for Predicting the Centrosome Hyperamplification in Bladder Cancer by Using DNA Microarray Data

Kazuhiro Tokunaga*, Fumiya Kubosaka**, Noriaki Suetake**,
Eiji Uchino*,**, and Hideyasu Matsuyama***

*Fuzzy Logic Systems Institute, 680-41 Kawazu, Iizuka, Fukuoka 820-0067, Japan

**Graduate School of Science and Engineering, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8512, Japan

***Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-kogushi, Ube 755-8505, Japan

Received:
November 19, 2012
Accepted:
February 1, 2013
Published:
March 20, 2013
Keywords:
DNA microarray, centrosome hyperamplification, reduction of feature dimension, t-test, Wilcoxon rank sum test
Abstract

In this paper, we propose a Computer Aided Diagnosis (CAD) system using a DNA microarray data for an early detection of a bladder cancer. In previous works, it is reported that one of the generating factors of the cancer cells is a centrosome hyperamplification. The centrosome hyperamplification is caused by a damage of DNA. Therefore, it is possible to detect the cancer by using the DNA microarray data. In this paper, the CAD system implemented based on a stochastic approach is proposed. The effectiveness of the present system is verified by the actual experiments.

Cite this article as:
Kazuhiro Tokunaga, Fumiya Kubosaka, Noriaki Suetake,
Eiji Uchino, and Hideyasu Matsuyama, “Diagnosis System for Predicting the Centrosome Hyperamplification in Bladder Cancer by Using DNA Microarray Data,” J. Adv. Comput. Intell. Intell. Inform., Vol.17, No.2, pp. 244-251, 2013.
Data files:
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