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JACIII Vol.17 No.2 pp. 244-251
doi: 10.20965/jaciii.2013.p0244
(2013)

Paper:

Diagnosis System for Predicting the Centrosome Hyperamplification in Bladder Cancer by Using DNA Microarray Data

Kazuhiro Tokunaga*, Fumiya Kubosaka**, Noriaki Suetake**,
Eiji Uchino*,**, and Hideyasu Matsuyama***

*Fuzzy Logic Systems Institute, 680-41 Kawazu, Iizuka, Fukuoka 820-0067, Japan

**Graduate School of Science and Engineering, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8512, Japan

***Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-kogushi, Ube 755-8505, Japan

Received:
November 19, 2012
Accepted:
February 1, 2013
Published:
March 20, 2013
Keywords:
DNA microarray, centrosome hyperamplification, reduction of feature dimension, t-test, Wilcoxon rank sum test
Abstract

In this paper, we propose a Computer Aided Diagnosis (CAD) system using a DNA microarray data for an early detection of a bladder cancer. In previous works, it is reported that one of the generating factors of the cancer cells is a centrosome hyperamplification. The centrosome hyperamplification is caused by a damage of DNA. Therefore, it is possible to detect the cancer by using the DNA microarray data. In this paper, the CAD system implemented based on a stochastic approach is proposed. The effectiveness of the present system is verified by the actual experiments.

Cite this article as:
K. Tokunaga, F. Kubosaka, N. Suetake, <. Uchino, and H. Matsuyama, “Diagnosis System for Predicting the Centrosome Hyperamplification in Bladder Cancer by Using DNA Microarray Data,” J. Adv. Comput. Intell. Intell. Inform., Vol.17, No.2, pp. 244-251, 2013.
Data files:
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