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IJAT Vol.12 No.1 pp. 45-51
doi: 10.20965/ijat.2018.p0045
(2018)

Review:

In Vitro Diagnostic Device with a Bio-Coupled Gate Field Effect Transistor

Toshiya Sakata

Department of Materials Engineering, School of Engineering, The University of Tokyo
7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

Corresponding author

Received:
June 9, 2017
Accepted:
November 23, 2017
Published:
January 5, 2018
Keywords:
biosensor, field-effect transistor, in vitro diagnosis (IVD)
Abstract

In this study, we report a simple and rapid biosensing method for the analysis and in vitro monitoring of biological processes, including DNAbinding events, antigen-antibody interactions, and cellular functions, using a semiconductor device. Most biological phenomena involve cell-cell communication processes that are mediated by the transport of sodium or potassium ions and other charged biomolecules, such as DNA, across ion channels in the cell membrane. Therefore, our approach focused on the direct detection of changes in ion concentrations by utilizing a semiconductor-based biosensor device. Our results demonstrated that our semiconductor-based biosensor platform achieves label-free and noninvasive biosensing that is suitable for in vitro diagnosis.

Cite this article as:
T. Sakata, “In Vitro Diagnostic Device with a Bio-Coupled Gate Field Effect Transistor,” Int. J. Automation Technol., Vol.12, No.1, pp. 45-51, 2018.
Data files:
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Last updated on Dec. 18, 2018