Positional Recognition and Attitude Control for 3-D Biomicromanipulation in Microscopy
Akiko Kawaji*, Fumihito Arai* and Toshio Fukuda**
*Department of Micro System Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8603, Japan
**Center for Cooperative Research in Advanced Sci. & Tech., Nagoya University
The biomicromanipulation so important to biology and bioengineering remains difficult because object used are very small, kept in liquids, or observed by optical microscopy. We are developing a micromanipulation system for anatomical operation of microobjects such as embryos, cells, and microbes. Microscope images are 2-D, so it is difficult to manipulate targets in 3-D space. To improve manipulation work, we proposed a 3-D biomicromanipulation system combined with virtual reality (VR) space. Here we propose the 3-D modeling method of the object to present 3-D visual information to the operator and improve the operation environment. In this system, we still have difficulty changing the orientation of the microscopic object by manipulating a mechanical manipulator. The bioaligner we propose is a microdevice for the positional control of an object. We developed a 2-D bioaligner by microfabrication. Here we show its fabrication process and basic rotating experiment with chlorella cells.
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