Earthquakes and tsunami disasters happen suddenly, devastating cities in just a few minutes. For decision makers to manage such disasters, they need current information on the status of their cities, but all information is collected separately and on paper now. All disaster-related information should be integrated to support decision making. To develop such an integrated system, Peru and Japan launched a new SATREPS project, “Development of Integrated Expert System for Estimation and Observation of Damage Level of Infrastructure in Lima Metropolitan Area,” in 2021. The project consists of four groups. Group 1 is related to earthquake and tsunami hazards, estimating the level of shaking and predicting the damage due to tsunami. Group 2 is related to damage detection/estimation, using sensing devices to estimate the level of damage to buildings and other infrastructure. Group 3 is related to understanding the damage over a wide area through satellite images, and also to the integration of all information from Groups 1 to 3. Group 4 is related to developing the capacity to utilize the integrated expert system. This special issue has been organized to present the progress accomplished in the first two years and to share the project’s achievements. It covers the fields of earthquake hazards, building and infrastructure damage estimation, damage estimation with satellite imagery, and human loss estimation.