Approaches of the JICA-AMED SATREPS Project to Controlling Outbreaks of Yellow Fever and Rift Valley Fever in Kenya
Department of Virology, Institute of Tropical Medicine, Nagasaki University
1-12-4 Sakamoto, Nagasaki City, Nagasaki 852-8523, Japan
Nagasaki University has conducted a JICA-AMED SATREPS project entitled “Development of Rapid Diagnostics and the Establishment of an Alert System for Outbreaks of Yellow Fever and Rift Valley Fever in Kenya.” This project, which ran for the 5-year period from January 2012 to January 2017, aimed to tackle yellow fever and Rift Valley fever in Kenya, as the name implies. The project was carried out in conjunction with the Kenya Medical Research Institute (KEMRI) and the Ministry of Health (MOH) of Kenya. The specific aims of this project were (1) the development of new diagnostics, (2) the strengthening of reference laboratories, and (3) the development of a disease outbreak alert system, particularly to control outbreaks of yellow fever (YF) and Rift Valley fever (RVF). The RVF virus IgM-capture ICT kit, “ImmunoLineTM,” and YF virus IgM-capture ELISA, “KemLisaTM,” were developed as new point-of-care tests. A neutralization test for the confirmation of these arbovirus infections was introduced to the central and local reference laboratories. This project also developed a new disease outbreak alert system, “mSOS,” which the MOH of Kenya has extended nationwide by integrating it into the national health information system (DHIS2).
-  Y. Nagai, “About the Japan initiative for global research network on infectious diseases (J-GRID)-an overview,” J. Disaster Res., Vol.9, No.5, pp. 768-773, 2014.
-  Y. Ichinose, “Kenya research station and its research activities,” J. Disaster Res., Vol.9, No.5, pp. 807-812, 2014.
-  S. Inoue, E. Wandera, G. Miringu, M. Bundi, C. Narita, S. Ashur, A. Kwallah, A. Galata, M. Abubakar, S. Suka, S. Mohamed, M. Karama, M. Horio, M. Shimada, and Y. Ichinose, “The NUITM-KEMRI P3 Laboratory in Kenya: Establishment, features, operation and maintenance,” Trop Med Health, Vol.41, No.1, pp. 27-37, 2013.
-  M. Bundi, G. Miring’u, S. Inoue, B. Muriithi, S. Ashur, E. Wandera, C. Kathiiko, E. Odoyo, C. Narita, A. Kwallah, A. Galata, A. Makumi, S. Huka, M. Shah, M. Karama, M. Shimada, S. Kariuki, M. Horio, and Y. Ichinose, “BSL-3 laboratory user training program at NUITM-KEMRI,” Trop Med Health, Vol.42, No.4, pp. 171-176, 2014.
-  S. Inoue, M. Bundi, G. Miringu, B. Muriithi, S. Ashur, E. Wandera, C. Kathiiko, E. Odoyo, A. Kwallah, A. Galata, S. Huka, M. Shah, M. Karama, S. Kariuki, and Y. Ichinose, “Evaluation of a BSL-3 laboratory biosafety training program in Kenya,” J. of Biotechnology and Biosafety, Vol.3, No.4, pp. 288-296, 2015.
-  A. Kwallah, S. Inoue, A. Muigai, T. Kubo, R. Sang, K. Morita, and M. Mwau, “A real-time reverse transcription loop-mediated isothermal amplification assay for the rapid detection of yellow fever virus,” J. Virological Methods, Vol.193, No.1, pp .23-27, 2013.
-  F. Adungo, Y. Fuxun, D. Kamau, S. Inoue, D. Hayasaka, P. H. Guillermo, R. Sang, M. Mwau, and K. Morita, “Development and characterisation of monoclonal antibodies to Yellow Fever Virus and their application in antigen detection and IgM capture ELISA,” Clinical and Vaccine Immunology, Vol.23, No.8, pp. 689-697, 2016.
-  A. Kwallah, S. Inoue, A. Muigai, N. Kuttoh, K. Morita, and M. Mwau, “Seroprevalence of Yellow Fever virus in selected health facilities in Western Kenya 2010–2012,” Jpn. J. Infect. Dis., Vol.68 No.3, pp. 230-234, 2015.
-  M. Omuyundo, “Prevalence of dengue viral infections among febrile patients in Mombasa County, Kenya,” Kenyatta University Thesis for M.Sc., online publication, pp. 1-83, 2014.
-  C. Wasonga, S. Inoue, J. Kimotho, K. Morita, J. Ongus, R. Sang, and L. Musila, “Development and evaluation of an in-house IgM-capture ELISA for the detection of chikungunya and application to a dengue outbreak situation in Kenya in 2013,” Jpn. J. Infect. Dis., Vol.68, No.5 pp. 410-414, 2015.
-  C. Wasonga, S. Inoue, C. Rumberia, G. Muchuki, J. Kimotho, J. Ongus, R. Sang, and L. Musila, “Genetic divergence of chikungunya virus plaques variants from the Comoros Island (2005),” Virus Genes, Vol.51, No.3, pp. 323-328, 2015.
-  M. Toda, I. Njeru, D. Zurovac, S. O-Tipo, D. Kareko, M. Mwau, and K. Morita, “Effectiveness of a mobile shortmessage-servicebased disease outbreak alert system in Kenya,” Emerging Infectious Diseases, Vol.22, No.4, pp. 711-715, 2016.
-  M. Toda, I. Njeru, D. Zurovac, D. Kareko, S. O-Tipo, M. Mwau, and K. Morita, “Understanding mSOS: A qualitative study examining the implementation of a text messaging outbreak alert system in rural Kenya,” PLOS One, Vol.12, No.6, e0179408, pp. 1-13, 2017.
This article is published under a Creative Commons Attribution-NoDerivatives 4.0 International License.