This paper deals with novel distributed route guidance that cooperates with self-organizing control of traffic signal networks. Self-organizing control of traffic signals provides a fully distributed approach to coordinate a number of signals distributed in a wide area based on local information of traffic flows so that split and offset control parameters between traffic signals are adjusted for efficient traffic flow. The self-organizing route guidance systems (SRGS) concept is introduced for efficient route guidance to facilitate offset adjustment of the self-organizing control of signal networks by self-organizing multilayered vector fields. Simulation demonstrates the effectiveness of the proposal under nonstationary traffic conditions.