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IJAT Vol.18 No.2 pp. 276-286
doi: 10.20965/ijat.2024.p0276
(2024)

Research Paper:

Effects of Mosquito-Imitated Microneedle’s Reciprocating Rotations on Puncture Resistance Forces—Evaluations by Puncturing Experiments and Nonlinear FEM Analyses—

Akira Mizutsu*1, Yuki Okumura*2, Atsushi Ueda*2, Shunki Yamamoto*1, Tomokazu Takahashi*1, Masato Suzuki*1 ORCID Icon, Seiji Aoyagi*1,† ORCID Icon, Toshio Nagashima*3 ORCID Icon, Makoto Chiyonobu*4, Hideki Nishikawa*5, Fumio Sudo*5, Toshiyuki Ohdaira*6, and Satoshi Seshimo*6

*1Kansai University
3-3-35 Yamate-cho, Suita, Osaka 564-8680, Japan

Corresponding author

*2Panasonic Holdings Corporation
Kadoma, Japan

*3Sophia University
Tokyo, Japan

*4JSOL Corporation
Osaka, Japan

*5FUTA-Q, Ltd.
Kyoto, Japan

*6Yamada Seiko Co., Ltd.
Uonuma, Japan

Received:
June 23, 2023
Accepted:
December 25, 2023
Published:
March 5, 2024
Keywords:
microneedle, mosquito, nonlinear FEM analysis, puncture experiment, reciprocating rotation
Abstract

Development of a low-invasive microneedle is currently desired in the medical field to mitigate the patients’ stress and pain. We have paid attention to mosquitoes that puncture the skin without giving humans no feelings of pain. We have observed mosquitoes and found that when their proboscis punctures human skin, they make the following three behaviors: apply tension to human skin; rotate their proboscis; vibrate their proboscis. In our previous studies, we developed a bundled set of three microneedle imitating the mosquito’s proboscis and experimentally proved the usefulness of their alternate vibrations, which is one of the mosquito’s puncturing behaviors. However, the setting of three needles with proper clearances from each other was difficult, making their driving system too complex to practically use it. Therefore, we have developed a simplified microneedle by reducing the number of needles from three to two or one. This paper has focused on the effects of the rotations of a single needle. Using our developed microneedle with a diameter of 90 µm and the thinnest commercial microneedle with a diameter of 180 µm, we evaluated the effect of reciprocating rotation, one of the mosquitoes’ puncturing behaviors, by puncture experiments using artificial skin and nonlinear finite element method (FEM) analysis. As a result, it was found that the reciprocating rotation suppresses the puncture resistance force and the skin deflection.

Cite this article as:
A. Mizutsu, Y. Okumura, A. Ueda, S. Yamamoto, T. Takahashi, M. Suzuki, S. Aoyagi, T. Nagashima, M. Chiyonobu, H. Nishikawa, F. Sudo, T. Ohdaira, and S. Seshimo, “Effects of Mosquito-Imitated Microneedle’s Reciprocating Rotations on Puncture Resistance Forces—Evaluations by Puncturing Experiments and Nonlinear FEM Analyses—,” Int. J. Automation Technol., Vol.18 No.2, pp. 276-286, 2024.
Data files:
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Last updated on Jun. 03, 2024