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IJAT Vol.10 No.6 pp. 950-957
doi: 10.20965/ijat.2016.p0950
(2016)

Paper:

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Fabrication of Stainless Steel Microneedle with Laser-Cut Sharp Tip and its Penetration and Blood Sampling Performance

Yasuhiro Hara*,†, Masahiro Yamada**, Chikako Tatsukawa*, Tomokazu Takahashi**, Masato Suzuki**, and Seiji Aoyagi**

*Organization for Research and Development of Innovative Science and Technology, Kansai University
3-3-35 Yamate-cho, Suita, Osaka 564-8680, Japan

†Corresponding author,

**Faculty of Engineering Science, Department of Mechanical Engineering, Kansai University
3-3-35 Yamate-cho, Suita, Osaka 564-8680, Japan

Received:
May 6, 2016
Accepted:
August 3, 2016
Published:
November 4, 2016
Creative Commons License
Keywords:
femtosecond laser machining, microneedle, biomimetic, mosquito, minimal invasiveness
Abstract
The demand for minimally invasive injection needles or needle-shaped tools is growing from those who carry out medical practices such as blood or insulin injections. Applying the mosquito biomimetic, we have used a femtosecond laser to fabricate minimally invasive microneedles out of ultrafine hollow SUS304 pipes, 50 μm in outer diameter and 20 μm in inner diameter. When such a stainless steel needle tip is angled at 15°, it has the lowest penetration resistance, two and a half times lower than that of the finest hollow needle that is commercially available. A blood suction experiment with a newly developed microneedle has demonstrated that 2.8 μell of blood can be drawn out in 20 seconds. Such stainless steel microneedles fabricated by femtosecond lasers have great potential as minimally invasive and mass-producible blood sampling needles to be used for diabetic inspections.
Cite this article as:
Y. Hara, M. Yamada, C. Tatsukawa, T. Takahashi, M. Suzuki, and S. Aoyagi, “Fabrication of Stainless Steel Microneedle with Laser-Cut Sharp Tip and its Penetration and Blood Sampling Performance,” Int. J. Automation Technol., Vol.10 No.6, pp. 950-957, 2016.
Data files:
References
  1. [1] P. K. Campbell, K. E. Jones, R. J. Huber, K. W. Horch, and R. A. Normann, “A Silicon-Based, Three-Dimensional Neural Interface: Manufacturing Processes for an Intracortical Electrode Array,” IEEE Trans. Biomed. Eng., Vol.38, No.8, pp. 758-768, 1991.
  2. [2] K. Najafi, J. Ji, and K. D. Wise, “Scaling Limitations of Silicon Multichannel Recording Probes,” J. Biomed. Eng., Vol.37, No.1, pp. 1-11, 1990.
  3. [3] S. Chandrasekaran, J. D. Brazzle, and A. B. Frazier, “Surface Micromachined Metallic Microneedles,” J. MEMS, Vol.12, No.3, pp. 281-288, 2003.
  4. [4] D. V. McAllister, F. Cross, S. P. Davis, L. M. Matta, M. R. Prausnitz, and M. G. Allen, “Three-Dimensional Hollow Microneedle and Microtube Arrays,” Proc. Transducers’ 99, pp. 1098-1101, 1999.
  5. [5] J. Park, S. Davis, Y. Yoon, M. R. Prausnitz, and M. G. Allen, “Micromachined Biodegradable Microstructures,” Proc. MEMS ’03, pp. 371-374, 2003.
  6. [6] N. Matsuzuka, Y. Hirai, and O. Tabata, “Prediction Method of 3-D Shape Fabricated by Double Exposure Technique in Deep X-ray Lithography (D2XRL),” Proc. MEMS ’06, pp. 186-189, 2006.
  7. [7] A. N. Clement, “The Biology of Mosquitoes,” CABI Publishing, pp. 224-234, 2000.
  8. [8] H. Izumi, M. Suzuki, S. Aoyagi, and T. Kanzaki, “Realistic Imitation of Mosquito’s Proboscis: Electrochemically Etched Sharp and Jagged Needles and Their Cooperative Inserting Motion,” Sens. Actuators, Vol.A165, pp. 115-123, 2011.
  9. [9] S. Aoyagi, H. Izumi, and M. Fukuda, “Biodegradable Polymer Needle with Various Tip Angles and Effect of Vibration and Surface Tension on Easy insertion,” Sens. Actuators, Vol.A143, pp. 20-28, 2008.
  10. [10] H. Izumi, T. Okamoto, M. Suzuki, and S. Aoyagi, “Development of a Silicon Microneedle with Three-Dimensional Sharp Tip by Electrochemical Etching,” IEEJ Trans. SM, Vol.129, pp. 373-379, 2009.
  11. [11] M. Suzuki, T. Sawa, T. Takahashi, and S. Aoyagi, “Fabrication of microneedle mimicking mosquito proboscis using nanoscale 3D laser lithography system,” Int. J. Automation Technol., Vol.9, No.6, pp. 655-661, 2015.
  12. [12] C-H. Huang, T. Tanaka, Y. Takaoki, H. Izumi, T. Takahashi, M. Suzuki, and S. Aoyagi, “Fabrication of metallic microneedle by electroplating and sharpening of it by electrochemical etching,” IEEJ Trans. SM, Vol.131, No.11, pp. 373-380, 2011 (in Japanese).
  13. [13] H. Gen, M. Oishi, T. Takahashi, M. Suzuki, S. Aoyagi, S. Matumoto, K. Suzuki, H. Ueda, Z. Haga, and H. Miyako, “Development of microneedle by injection molding using heat and cool method,” Proc. Annual autumn meeting Jpn. Prec. Engineering, pp. 829-830, 2015.
  14. [14] P. P. Pronko, S. K. Dutta, J. Squier, J. V. Rudd, D. Du, and G. Mourou, “Machining of sub-micron holes using a femtosecond laser at 800 nm,” Opt. Commum, Vol.114, pp. 106-110, 1995.
  15. [15] C. Momma, B. N. Chichkov, S. Nolte, F. V. Alvensleben, A. Tiinnermann, H. Welling, and B. Wellegehausen, “Short-pulse laser ablation of solid targets,” Opt. Commum, Vol.129, pp. 134-142, 1996.
  16. [16] M. Fujita and M. Hasida, “Femtosecond-Laser Processing,” J. Plasma Fusion Res., Vol.81, Suppl. pp. 195-201, 2005 (in Japanese).
  17. [17] The Laser Society of Japan, “Laser Handbook, the second edition,” p. 832, 2005 (in Japanese).
  18. [18] Terumo corporation website, https://www.terumo.co.jp/medical/equipment/me104.html, [accessed April 30, 2016]
  19. [19] NIPRO corporation website, http://sales.nipro.co.jp/freestyle/product/ [accessed April 30, 2016]

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