Letter:
Wearable Biosensor Utilizing Chitosan Biopolymer for Uric Acid Monitoring
Mizuki Sato*1, Tatsuya Kamiyama*2, Kenta Iitani*3
, Kazuyoshi Yano*4, Kohji Mitsubayashi*3
, and Takahiro Arakawa*1,*2
*1Graduate School of Engineering, Tokyo University of Technology
1404-1 Katakura, Hachioji, Tokyo 192-0982, Japan
*2Department of Electric and Electronic Engineering, School of Engineering, Tokyo University of Technology
1404-1 Katakura, Hachioji, Tokyo 192-0982, Japan
*3Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan
*4Graduate School of Bionics, Computer and Media Sciences, Tokyo University of Technology
1404-1 Katakura, Hachioji, Tokyo 192-0982, Japan
A wearable biosensor was specifically engineered to measure uric acid, a biomarker present at wound sites. This biosensor, fabricated as a disposable and wearable device, was seamlessly integrated onto a polyethylene terephthalate (PET) substrate by utilizing carbon and silver conductive paste as the electrodes. The enzyme uricase was immobilized onto the working electrode by utilizing chitosan, a biocompatible material, to create this biosensor. Notably, the uric acid biosensor fabricated with chitosan showcased exceptional performance metrics, including remarkable output current values and impeccable stability. These findings suggest the prospective utilization of chitosan-based uric acid biosensors for the accurate measurement of uric acid on human skin in future applications.
Uric acid biosensor for skin monitoring
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