Neural Interface for Biohybrid Prosthetic Hands to Realize Sensory and Motor Functions

Tohru Yagi; Zugui Peng; Shoichiro Kanno

doi:10.20965/jrm.2022.p0316

single-rb.php

« previous

JRM Vol.34 No.2 pp. 316-318

doi: 10.20965/jrm.2022.p0316

(2022)

Letter:

Views over last 60 days: 508

Neural Interface for Biohybrid Prosthetic Hands to Realize Sensory and Motor Functions

Tohru Yagi, Zugui Peng, and Shoichiro Kanno

Tokyo Institute of Technology
2-12-1 Ookayama, Meguro, Tokyo 152-8552, Japan

Received:

September 20, 2021

Accepted:

November 4, 2021

Published:

April 20, 2022

Keywords:

neural interface, DNA nanotechnology, axon guidance, prosthetic arm

Abstract

A neural interface is a technology that facilitates communication between the brain and external devices. One potential clinical application of a neural interface is in prosthetic arms. These devices can realize motor and sensory functions, enabling amputee patients to perform daily tasks. However, such prosthetic arms are still challenging because of the poor resolution of conventional neural electrodes and the difficulty in sorting the motor and sensory nerve cells. In this study, we attempt to utilize deoxyribonucleic acid (DNA) nanotubes to develop a novel intracellular electrode with high resolution. Our results indicate that DNA nanotubes can transport ions, such as Ca²⁺. Moreover, a microchannel device for sorting motor and sensory nerves is introduced.

Schematic image of biohybird prosthetic arm

Cite this article as:

T. Yagi, Z. Peng, and S. Kanno, “Neural Interface for Biohybrid Prosthetic Hands to Realize Sensory and Motor Functions,” J. Robot. Mechatron., Vol.34 No.2, pp. 316-318, 2022.

Data files:

References

[1] M. Ortiz-Catalan, E. Mastinu, P. Sassu, O. Aszmann, and R. Brånemark, “Self-contained neuromusculoskeletal arm prostheses,” The New England J. of Medicine, Vol.382, No.18, pp. 1732-1738, doi: 10.1056/NEJMoa1917537, 2020.
[2] M. Spira and A. Hai, “Multi-electrode array technologies for neuroscience and cardiology,” Nat. Nanotechnol., Vol.8, pp. 83-94, doi: 10.1038/nnaNo.2012.265, 2013.
[3] J. T. Robinson, M. Jorgolli, A. K. Shalek, M.-H. Yoon, R. S. Gertner, and H. Park, “Vertical nanowire electrode arrays as a scalable platform for intracellular interfacing to neuronal circuits,” Nat. Nanotechnol., Vol.7, pp. 180-184, doi: 10.1038/nnano.2011.249, 2012.
[4] J. Burns, A. Seifert, N. Fertig, and S. Howorka, “A biomimetic DNA-based channel for the ligand-controlled transport of charged molecular cargo across a biological membrane,” Nat. Nanotechnol., Vol.11, pp. 152-156, doi: 10.1038/nnano.2015.279, 2016.

This article is published under a Creative Commons Attribution-NoDerivatives 4.0 Internationa License.

[1] [1] M. Ortiz-Catalan, E. Mastinu, P. Sassu, O. Aszmann, and R. Brånemark, “Self-contained neuromusculoskeletal arm prostheses,” The New England J. of Medicine, Vol.382, No.18, pp. 1732-1738, doi: 10.1056/NEJMoa1917537, 2020.

[2] [2] M. Spira and A. Hai, “Multi-electrode array technologies for neuroscience and cardiology,” Nat. Nanotechnol., Vol.8, pp. 83-94, doi: 10.1038/nnaNo.2012.265, 2013.

[3] [3] J. T. Robinson, M. Jorgolli, A. K. Shalek, M.-H. Yoon, R. S. Gertner, and H. Park, “Vertical nanowire electrode arrays as a scalable platform for intracellular interfacing to neuronal circuits,” Nat. Nanotechnol., Vol.7, pp. 180-184, doi: 10.1038/nnano.2011.249, 2012.

[4] [4] J. Burns, A. Seifert, N. Fertig, and S. Howorka, “A biomimetic DNA-based channel for the ligand-controlled transport of charged molecular cargo across a biological membrane,” Nat. Nanotechnol., Vol.11, pp. 152-156, doi: 10.1038/nnano.2015.279, 2016.