On-Chip Particle Sorting into Multiple Channels by Magnetically Driven Microtools
Masaya Hagiwara*, Miyako Niimi*, Tomohiro Kawahara*,
Yoko Yamanishi**, Hayao Nakanishi***, and Fumihito Arai*
*Department of Mechanical Science & Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8603, Japan
**JST PRESTO, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8603, Japan
***Aichi Cancer Center Research Institute, Chikusa-ku, Nagoya, Aichi 464-8682, Japan
This paper presents a new type of sorting system by magnetic microtools (MMT) separating particles into multiple channels. Two nickel-based MMTs are activated by commercially available permanent magnets below the biochip to lead particles to certain channels via fluid force. The horizontally assembled permanent magnet drive we developed shows that the MMT positioning accuracy had been improved 5 times in 2 degrees of freedom. The channel and the MMT shape are determined based on FEM analysis to ensure that particles flow smoothly. We have successfully achieved to sort 100 µm diameter microbeads into 7 branched channels. The noncontact drive and disposable chip provide a less invasive environment for the cell with low cost.
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