single-dr.php

JDR Vol.8 No.4 pp. 705-713
(2013)
doi: 10.20965/jdr.2013.p0705

Paper:

Dual-Use Research and the Myth of Easy Replication

Sonia Ben Ouagrham-Gormley

Biodefense Program, Department of Public and International Affairs, George Mason University, Fairfax, Virginia, USA

Received:
April 1, 2013
Accepted:
July 10, 2013
Published:
August 1, 2013
Keywords:
dual-use research of concern (DURC), replication of dual-use research, misuse of dual-use research, bioweapons, terrorism, NSABB, H5N1
Abstract
Since 2000 a number of controversial research projects have raised concerns that states or terrorist groups might use published research results to replicate the work for malevolent purposes. The issue came into greater focus in December 2011, after it was revealed that the U.S.-based National Science Advisory Board for Biosecurity had requested one U.S. and another Dutch lab to halt publication of work describing what was done to enhance the transmissibility of the H5N1 flu virus to mammals. In spite of a decade of debate and policy development to prevent bio-attacks and the misuse of dual-use research, little effort has been made to determine whether scientific publications can indeed help replication by untrained individuals. This paper taps into the extensive science and technology literature and recent studies in the security field, to show that replication of scientific work is inherently difficult and probably inaccessible to untrained individuals. The paper also offers new policy options designed to more effectively prevent the misuse of dual-use research.
Cite this article as:
S. Ouagrham-Gormley, “Dual-Use Research and the Myth of Easy Replication,” J. Disaster Res., Vol.8 No.4, pp. 705-713, 2013.
Data files:
References
  1. [1] D. G. McNeil Jr., “Bird Flu Paper is Published After Debate,” New York Times, June 21, 2012,
    http://www.nytimes.com/2012/06/22/health/h5n1-bird-flu-research-that-stoked-fears-is-published.html [accessed July 12, 2013]
  2. [2] The NSABBB is an organization created in 2004 in the wake of the anthrax letters of 2001 to advise the US government on strategies to prevent the misuse of dual-use research.
  3. [3] Cases of H5N1 transfer from birds to humans are rare, occurring only when individuals are in close contact with infected poultry. To date, 565 people have been infected worldwide, 60 percent died; “Press Statement on the NSABBB Review of H5N1 Research,” NIH News, December 20, 2011,
    http://www.nih.gov/news/health/dec2011/od-20.htm [accessed July 12, 2013]
  4. [4] D. MacKenzie, “Five Easy Mutations to Make Bird Flu a Lethal Pandemic,” New Scientist, September 26, 2011,
    http://www.newscientist.com/article/mg21128314.600-five-easy-mutations-tomake-bird-flu-a-lethal-pandemic.html [accessed July 12, 2013]
  5. [5] N. Houser, “Mutated H5N1 Virus Created in Netherlands Research Lab,” Digital Journal, Dec. 25, 2011,
    http://www.digitaljournal.com/article/316682 [accessed July 12, 2013]
  6. [6] S. Connor, “Too Late to Contain Killer Flu Science, Say Experts,” The Independent, December 22, 2011,
    http://www.independent.co.uk/news/science/too-late-to-contain-killer-flu-science-say-experts-6280399.html [accessed July 12, 2013]
  7. [7] Interview with Dr. Anthony Fauci, from the Institute of Allergy and Infectious Disease, in “Biomedical Experiments and Public Safety,” Diane Rehm Show, NPR, December 20, 2011,
    http://thedianerehmshow.org/shows/2011-12-22/biomedicalexperiments-and-public-safety/transcript [accessed July 12, 2013]
  8. [8] S. Ben Ouagrham-Gormley, “Barriers to Bioweapons: Knowledge, Organization, Integration,” Cornell University Press (forthcoming).
  9. [9] R. Trapp, “Advances in Science and Technology and the Chemical Weapons Convention,” Arms Control Today, Vol.38, No.2, pp. 18-22, March, 2008,
    http://www.armscontrol.org/act/2008_03/Trapp [accessed July 12, 2013]
  10. [10] J. Tucker, “The Body’s Own Weapons,” Bulletin of the Atomic Scientists, Vol.64, No.1, pp. 16-22, March/April 2008.
  11. [11] “Interview: Drew Endy,” Bulletin of the Atomic Scientists, Vol.63, No.3, May/June, 2007.
  12. [12] R. Carlson, “The Pace and Proliferation of Biological Technologies” Biosecurity and Bioterrorism: Biodefense Strategy, Practice, and Science, Vol.1, No.3, pp. 203-214, 2003.
  13. [13] J. Tucker and R. Zilinskas, “The Promise and Perils of Synthetic Biology,” The New Atlantis, No.12, pp. 25-45, Spring, 2006.
  14. [14] U.S. Congress, Office of Technology Assessment, Technologies Underlying Weapons of Mass Destruction, OTA-BP-ISC-115, Washington, D.C., U.S. GPO, December, 1993.
  15. [15] G. L. Epstein, “The Challenge of Developing Synthetic Pathogens,” Bulletin of the Atomic Scientists, May 19, 2008,
    http://thebulletin.org/challenges-developing-synthetic-pathogens [accessed July 12, 2013]
  16. [16] J. B. Tucker, “Double-Edged DNA: Preventing the Misuse of Gene Synthesis,” Issues in Science and Technology, Spring, 2010,
    http://www.issues.org/26.3/tucker.html [accessed July 12, 2013]
  17. [17] J. Randerson, “Revealed: the Lax Laws that Could Allow Assembly of Deadly virus DNA,” The Guardian, June 14, 2006,
    http://www.guardian.co.uk/world/2006/jun/14/terrorism.topstories3 [accessed July 12, 2013]
  18. [18] J. Randerson, “No Action on Bio-Terrorism Loophole,” The Guardian, August 1, 2006,
    http://www.guardian.co.uk/science/2006/aug/01/terrorism.politics [accessed July 12, 2013]
  19. [19] E. Check, “Synthetic Biologists Face Up to Security Issues,” Nature, Vol.436, pp. 894-895, August 17, 2005.
  20. [20] A bacteriophage is a virus that infects bacteria; An oligonnucleotide is a short strand of nucleic acids.
  21. [21] USA PATRIOT Act, 2002; Public Health Security and Bioterrorism Preparedness and Response Act, 2002; Army Regulation 50-1, 2004 and 2008; and United States Government Policy for Oversight of Life Sciences Dual Use Research of Concern, 2012.
  22. [22] National Research Council, “Biotechnology Research in an Age of Terrorism,” Washington, D.C, National Academies Press, 2004.
  23. [23] J. B. Tucker, “Developing Medical Countermeasures: From BioShield to BARDA,” Drug Development Research, Vol.70, No.4, pp. 224-233, 2009.
  24. [24] P. K. Russell and G. K. Gronvall, “U.S. Medical Countermeasure Development Since 2001: A long Way Yet to Go,” Biosecurity and Bioterrorism: Biodefense Strategy, Practice, and Science, Vol.10, No.1, pp. 66-76, 2012.
  25. [25] D. Willman, “The Biodefender that Cries Wolf,” Los Angeles Times, July 7, 2012,
    http://articles.latimes.com/2012/jul/07/nation/la-na-biowatch-20120708 [accessed July 12, 2013]
  26. [26] Institute of Medicine, “BioWatch and Public Health Surveillance: Evaluating Systems for the Early Detection of Biological Threats: Abbreviated Version,” Washington, DC: National Academies Press, 2011.
  27. [27] D. Willman, “BioWatch Technology Couldn’t Detect Lethal Germs, Tests Found,” Los Angeles Times, October 22, 2012,
    http://articles.latimes.com/2012/oct/22/nation/la-na-biowatchfaulty-assays-20121023 [accessed July 12, 2013]
  28. [28] D. Franz, “Balancing Science and Security,” Presentation at the seminar on Pandemic, Bioterrorism, and International Security, Fairfax, VA, July 23-25, 2012.
  29. [29] J. Kaiser, “Resurrected Influenza Virus Yields Secrets of Deadly 1918 Pandemic,” Science Magazine, Vol.310, No.77, pp. 28-29, October 7, 2005.
  30. [30] D. Carvajal, “Security in Flu StudyWas Paramount, Scientist Says,” New York Times, December 21, 2011,
    http://www.nytimes.com/2011/12/22/health/security-in-h5n1-bird-flu-study-was-paramountscientist-says.html?pagewanted= all [accessed July 12, 2013]
  31. [31] G. Colata, “Polio Synthesis in the Test Tube,” New York Times, December 13, 1991,
    http://www.nytimes.com/1991/12/13/us/poliosynthesized-in-the-test-tube.html [accessed July 12, 2013]
  32. [32] Vogel, “Phantom Menace or Looming Danger?” and Kathleen M. Vogel, “Framing Biosecurity: An Alternative to the Biotech Revolution Model?” Science and Public Policy, Vol.35, No.1, pp. 45-54, February, 2008.
  33. [33] J. C. Venter, “A Life Decoded, My Genome: My Life,” New York, NY: Viking, 2007, pp. 102-107.
  34. [34] Science Channel documentary, “Creating Synthetic Life,” 2010; see also Venter Institute, “First Self-Replicating Synthetic Bacterial Cell,” Press Release, May 20, 2010,
    http://www.jcvi.org/cms/press/press-releases/full-text/article/first-self-replicating-syntheticbacterial-cell-constructed-by-j-craig-venter-institute-researcher/ [accessed July 12, 2013]
  35. [35] Author interview with former Soviet bioweapon scientist Igor Domaradskij, Moscow, Russia, June 3, 2008.
  36. [36] F. Reif, “The Competitive World of Pure Scientists: The Quest for Prestige can cause Conflict Between the Goals of Science and the Goals of the Scientist,” Science, Vol.134, No.3494, pp. 1957-62, December 15, 1961.
  37. [37] K. Jordan and M. Lynch, “The Sociology of a Genetic Engineering Technique: Ritual and Rationality in the performance of a ���Plasmid Prep’,” in A. E. Clarke and J. H. Fujimura (Eds.), “The Right Tools for the Job: At Work in Twentieth- Century Life Sciences,” Princeton, NJ: Princeton University Press, pp. 77-114.
  38. [38] M. Lynch, “Protocols, Practices, and the Reproduction of Technique in Molecular Biology,” British Journal of Sociology, Vol.53, No.2, pp. 203-220, June, 2002.
  39. [39] A. Cambrioso and P. Keating, “Going Monoclonal: Art, Science, and Magic in the Day-to-Day Use of Hybridoma Technology,” Social Problems, Vol.35, No.3, pp. 244-260, June, 1988.
  40. [40] S. Ben Ouagrham-Gormley, “Barriers to Bioweapons: Intangible Obstacles to Proliferation,” International Security, Vol.36, No.4, pp. 80-114, Spring, 2012.
  41. [41] S. Ben Ouagrham-Gormley and K. Vogel, “The Social Context Shaping Bioweapons (Non)proliferation,” Biosecurity and Bioterrorism: Biodefense Strategy, Practice, and Science, Vol.8, No.1, pp. 9-24, March, 2010.
  42. [42] Author interviews with various PCR users,Washington D.C., 2010-11.
  43. [43] V. de Lorenzo, “Not Really New,” Lab Times, pp. 20-24, March, 2009,
    http://www.labtimes.org/labtimes/issues/lt2009/lt03/lt_2009_03_20_25.pdf [accessed July 12, 2013]
  44. [44] R. Kwok, “Five Hard Truths for Synthetic Biology,” Nature, Vol.463, pp. 288-290, January 2010.
  45. [45] These are temporary results from the author’s current research project on scientific education in the United States. The author uses ranking of U.S. universities provided by the U.S. New &World Report.
  46. [46] J. Guillemin, “Scientists and the History of Biological Weapons: A Brief Historical Overview of the Development of Biological Weapons in the Twentieth Century,” EMBO Reports, pp. 45-49, July, 2006,
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1490304/ [accessed July 12, 2013]
  47. [47] M. Dando, “Bringing Increased Biological and Chemical Weapons Provisions to the ICC,” Bulletin of the Atomic Scientists Online, November 11, 2009,
    http://thebulletin.org/bringing-increasedbiological-and-chemical-weapons-provisions-icc [accessed July 12, 2013]
  48. [48] Author interviews with former U.S. and Soviet bioweapons scientists from 2006-11.
  49. [49] The Anthrax Diaries, documentary produced by Slawomir Grunberg, Sonia Ben Ouagrham-Gormley, Slava Paperno, and Kathleen Vogel, 2012,
    http://virtualbiosecuritycenter.org/videos/the-anthraxdiaries [accessed July 12, 2013]
  50. [50] B. Balmer, “Killing Without the Distressing Preliminaries: Scientists’ Defence of the British Biological Warfare Programme,” Minerva, Vol.40, No.1, pp. 57-75, 2002.
  51. [51] Author interview with anonymous scientist, Fairfax, VA, July 2012.
  52. [52] Public Health Security and Bioterrorism Preparedness and Response Act, 2002.
  53. [53] Department of Health and Human Services, “United States Government Policy for Institutional Oversight of Life Sciences Dual Use Research of Concern,” February, 2013,
    https://www.phe.gov/s3/dualuse/Pages/default.aspx [accessed July 12, 2013]
  54. [54] Edward You, WMD Coordinator, FBI, Statement Before the Presidential Commission on Bioethics, July 9, 2010, Meeting 1, Session 7, 17-24.
  55. [55] K. Allen, S. Spence, and R. E. Leal, “Chemical and Biological Weapons Use in the Rome Statute: A Case for Change,” Vertic Brief, February 14, 2011,
    http://www.vertic.org/media/assets/Publications/VB%2014.pdf [accessed July 12, 2013]
  56. [56] U.S. Department of Health and Human Services, NIH News, “Press Statement on the NSABB Review of H5N1 Research,” December 20, 2011, available at:
    http://www.nih.gov/news/health/dec2011/od-20.htm [accessed July 12, 2013]
  57. [57] D. MacKenzie, “Five Easy Mutations to Make Bird Flu a Lethal Pandemic,” New Scientist, September 26, 2011,
    http://www.newscientist.com/article/mg21128314.600-five-easy-mutations-tomake-bird-flu-a-lethal-pandemic.html [accessed July 12, 2013]
  58. [58] Discussion of NSABB’s publication recommendations for the NIH-funded research on the transmissibility of H5N1, 29 February 2012, 2013 ASM Biodefense and Emerging Diseases Research Meeting, available at:
    http://mediasuite.multicastmedia.com/player.php?p=rxmwj814 [accessed July 12, 2013]
  59. [59] Title 18 of the U.S. Code, section 175 – Prohibitions with Respect to Biological Weapons,
    http://www.law.cornell.edu/uscode/text/18/175 [accessed July 12, 2013]
  60. [60] D. A. Shea, “Oversight of Dual-Use Biological Research: The National Science Advisory Board for Biosecurity,” CRS Report for Congress, April 27, 2007,
    http://www.fas.org/sgp/crs/natsec/RL33342.pdf [accessed July 15, 2013]
  61. [61] M. Enserink, “For Young Scientists, A Wild Ride,” Science, Vol.336, p. 1495, June 22, 2012.

*This site is desgined based on HTML5 and CSS3 for modern browsers, e.g. Chrome, Firefox, Safari, Edge, Opera.

Last updated on Apr. 22, 2024