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IJAT Vol.7 No.3 pp. 353-358
doi: 10.20965/ijat.2013.p0353
(2013)

Paper:

Modeling and Analysis of the Droplet Landing Process in Cell Direct-Writing

Cai Renye*,** and Huang Jin*,**

*Key Laboratory of Electronic Equipment Structure Design, Ministry of Education, Xidian University, 2 South Taibai Road, Xi’an, China

**Research Institute on Mechatronics, Xidian University, 2 South Taibai Road, Xi’an, China

Received:
December 14, 2012
Accepted:
March 14, 2013
Published:
May 5, 2013
Keywords:
cell printing and direct-write, impact, cell damage
Abstract

Cell direct-write, a promising technology for the creation of complex, three-dimensional tissue constructs, has great potential in tissue engineering, biological cytology, high-throughput drug screening and cell sensors. However, it has been found that cell damage due to the mechanical impact during cell direct-write is a possible hurdle for broad applications of fragile cell direct writing. The objective of this paper is to analyze the impact of the continuously jetted cell droplets on the hydro-gel coating substrate. In order to avoid the element distortion due to large-scale deformation, a mesh-free Smooth Particle Hydrodynamic method (SPH), is introduced to study the impact-induced cell mechanical loading profile during cell landing, including effective stress, plastic strain, velocity and acceleration, for better understanding and prediction of possible impact-induced cell damage. It is found that three important impact processes, cell-hydrogel, cellcell and cell-substrate impact, may occur during cell landing. It is concluded to decrease impact-induced cell damage, there are an appropriate firing period and jetting velocity.

Cite this article as:
C. Renye and H. Jin, “Modeling and Analysis of the Droplet Landing Process in Cell Direct-Writing,” Int. J. Automation Technol., Vol.7, No.3, pp. 353-358, 2013.
Data files:
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Last updated on Dec. 05, 2019