single-au.php

IJAT Vol.4 No.3 pp. 291-302
doi: 10.20965/ijat.2010.p0291
(2010)

Paper:

Machining Porous Calcium Polyphosphate Implants for Tissue Engineering Applications

Amir Rouzrokh*, Christina Yi-HsuanWei*, Kaan Erkorkmaz*, and Robert M. Pilliar**

*Department of Mechanical & Mechatronics Engineering, University of Waterloo, 200 University Ave West, Waterloo, Ontario N2L 3G1, Canada

**Faculty of Dentistry, Institute of Biomaterials & Biomedical Engineering, University of Toronto, 124 Edward Street, Toronto, Ontario M5G 1G6, Canada

Received:
January 11, 2010
Accepted:
March 26, 2010
Published:
May 5, 2010
Keywords:
calcium polyphosphate, milling, 5-axis machining, tissue engineering
Abstract
The emergence of biodegradable bone substitute materials promises new breakthroughs in the field of tissue engineering. However, such materials like Hydroxyapatite and Calcium Polyphosphate (CPP) are relatively new in the world of manufacturing. Reliable processing data is required in order optimize the production of biomedical implants made from these materials. This paper investigates the machining characteristics of CPP.Milling studies are conducted to determine the suitable cutting speeds and conditions which produce accurately machined porous surfaces. This is required for the CPP material to fulfill its biomedical function. A force model is also developed by identifying the cutting coefficients, which helps to predict and limit the machining forces, thereby avoiding unwanted chipping of the implant. Results of these studies have been successfully incorporated into planning the 5-axis machining of a CPP construct for a tissue engineered tibial-plateu (lower knee joint) implant.
Cite this article as:
A. Rouzrokh, C. Yi-HsuanWei, K. Erkorkmaz, and R. Pilliar, “Machining Porous Calcium Polyphosphate Implants for Tissue Engineering Applications,” Int. J. Automation Technol., Vol.4 No.3, pp. 291-302, 2010.
Data files:
References
  1. [1] B. Levine, “A new era in porous metals: Applications in Orthopaedics, in Porous Metals and Metallic Foams,” eds. L.P. Lefebvre, J. Banhart, D.C. Dunand, DEStech Publications Inc., Lancaster, PA, pp. 251-254, 2008.
  2. [2] M. Kamitakahara, C. Ohtsuki, and T. Miyazaki, “Review Paper: Behavior of Ceramic Biomaterials Derived from Tricalcium Phosphate in Physiological Condition”, J. Biomater Appl, 23, pp. 197-212, 2008.
  3. [3] A. M. Pietak, J. W. Reid, M. J. Scott, and M. Sayer, “Silicon Substitution in the Calcium Phosphate Bioceramics,” Biomaterials, 28, pp. 4023-4032, 2007.
  4. [4] P. Habibovic, M. C. Kruyt, M. V. Juhl, S. Clyens, R. Martinetti, L. Dolcini, N. Theilgaard, and C. A. van Blitterswijk, “Comparative In Vivo Study of Six Hydroxyapatite-based Bone Graft Substitutes,” J. Ortho Res, 26, pp. 1363-1370, 2008.
  5. [5] P. Habibovic, H. Yuan, C. M. van der Valk, G. Meijer, C. A. van Blitterswijk, and K. de Groot, “3D Microenvironment as Essential Element for Osteoinduction by Biomaterials,” Biomaterials, 26, pp. 3565-3575, 2005.
  6. [6] R. C. Ropp, “Inorganic polymeric glasses,” Elsevier, Amsterdam, 1992.
  7. [7] R. M. Pilliar, M. J. Filiaggi, J. D. Wells, M. D. Grynpas, and R. A. Kandel, “Porous Calcium Polyphosphate Scaffolds for Bone Substitute Applications – In Vitro Characterization,” Biomaterials, 22, pp. 963-972, 2001.
  8. [8] M. Filiaggi, R.M. Pilliar, and J. Hong, “On the Sintering Characteristics of Calcium Polyphosphates,” Key Engineering Materials, 192-195, pp. 171-174, 2001.
  9. [9] M. D. Grynpas, R. M. Pilliar, M. J. Filiaggi, and R.A. Kandel, “Porous Calcium Polyphosphate Scaffolds for Bone Substitute Applications – In Vivo Characterization,” Biomaterials, 23, pp. 2063-2070, 2002.
  10. [10] R. A. Kandel, M. D. Grynpas, R. M. Pilliar, J. Lee, S. D.Waldman, P. Zalzal, and M. Hurtig, “Repair of Osteochondral Defects with Biphasic Cartilage-Calcium Polyphosphate Constructs In a Sheep Model,” Biomaterials, 27, pp. 4120-4131, 2006.
  11. [11] R. M. Pilliar, R. A. Kandel, and M. D. Grynpas, “Porous Calcium Polyphosphates for Musculoskeletal Repair and Regeneration,” Invited Plenary Presentation, Bioceramics 22, Daegu, Korea, Oct 26-29, 2009.
  12. [12] L. Gan, C. Tse, R. M. Pilliar, and R. A. Kandel, “Low-Power Laser Stimulation of Tissue Engineered Cartilage Tissue Formed on a Porous Calcium Polyphosphate Scaffold,” Lasers Surg Med., 39, pp. 286-293, 2007.
  13. [13] S. D. Waldman, D. C. Couto, M. D. Grynpas, R. M. Pilliar, and R. A. Kandel, “Multi-Axial Mechanical Stimulation of Tissue Engineered Cartilage,” Eur Cell Mater, 13, pp. 66-73, 2007.
  14. [14] K. Allan, R. M. Pilliar, J. Wang, M. D. Grynpas, and R. A. Kandel, “Formation of Biphasic Constructs Containing Cartilage with a Calcified Zone Interface,” Tissue Engineering, 13, pp. 167-77, 2007.
  15. [15] T. Kasuga, M. Terada, and M. Nogami, “Machinable Calcium Pyrophosphate Glass-Ceramics,” J. Materials Research, 16-3, pp. 876-880, 2001.
  16. [16] T. Kasuga, M. Nogami, and M. Niinomi, “Novel Machinable Calcium Phosphate Glass-Ceramics for Biomedical Use,” Materials Science Forum, 426, 432, pp. 3183-3188, 2003.
  17. [17] K. L. Chelulea, T. J. Cooleb, and D. G. Cheshire, “An Investigation into the Machinability of Hydroxyapatite for Bone Restoration Implants,” J. Materials Processing Technology, 135-2,3, pp. 242-246, 2002.
  18. [18] E. Budak, Y. Altintas, and E. J. A. Armarego, “Prediction ofMilling Force Coefficients from Orthogonal Cutting Data,” ASME J. Manufacturing Science and Engineering, 118, pp. 216-224, 1996.
  19. [19] Y. Altintas, “Manufacturing Automation: Principles of Metal Cutting and Machine Tool Control,” Cambridge University Press, UK, 2000.
  20. [20] P. Lee and Y. Altintas, “Prediction of Ball-End Milling Forces from Orthogonal Cutting Data,” Int. J. Machine Tools and Manufacture, 36-9, pp. 1059-1072, 1996.
  21. [21] A. Dudi and M. Papini, “Design of a Prototype Bioresorbable Tibial Implant in a Sheep Model,” Proc. 21st Canadian Congress of Applied Mechanics (CANCAM’07), Toronto, June 3-7, 2007.

*This site is desgined based on HTML5 and CSS3 for modern browsers, e.g. Chrome, Firefox, Safari, Edge, Opera.

Last updated on Apr. 22, 2024